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Titolo:
ALTERED FRONTOSTRIATAL RELATIONSHIP IN UNMEDICATED SCHIZOPHRENIC-PATIENTS
Autore:
BIVER F; GOLDMAN S; LUXEN A; DELVENNE V; DEMAERTELAER V; DELAFUENTE J; MENDLEWICZ J; LOTSTRA F;
Indirizzi:
ERASME UNIV HOSP,DEPT PSYCHIAT,ROUTE LENNIK 808 B-1070 BRUSSELS BELGIUM FREE UNIV BRUSSELS,ERASME HOSP,PET BIOMED CYCLOTRON UNIV B-1050 BRUSSELS BELGIUM FREE UNIV BRUSSELS,IRIBHN,DEPT STAT B-1050 BRUSSELS BELGIUM
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 61, anno: 1995,
pagine: 161 - 171
SICI:
0925-4927(1995)61:3<161:AFRIUS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; PROGRESSIVE SUPRANUCLEAR PALSY; PREFRONTAL CORTEX; DOPAMINE-RECEPTORS; BASAL GANGLIA; FRONTAL-LOBE; NEUROLEPTICS; DEPRESSION; CIRCUITS;
Keywords:
FRONTAL CORTEX; BASAL GANGLIA; POSITRON EMISSION TOMOGRAPHY; GLUCOSE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
F. Biver et al., "ALTERED FRONTOSTRIATAL RELATIONSHIP IN UNMEDICATED SCHIZOPHRENIC-PATIENTS", PSYCHIATRY RESEARCH-NEUROIMAGING, 61(3), 1995, pp. 161-171

Abstract

Positron emission tomography with [F-18]-fluoro-2-deoxy-D-glucose as tracer was used to investigate frontal glucose metabolism in 15 unmedicated schizophrenic patients and 15 healthy subjects under resting conditions. Although no difference in absolute frontal cerebral metabolicrates of glucose (CMR(glu)) were found between schizophrenic patientsand control subjects, relative measures significantly differentiated the two groups. Whole frontal metabolism and frontocaudate ratio were significantly decreased in both hemispheres in the patients. The results confirm the existence of hypofrontality in unmedicated schizophrenia and indicate disturbances in metabolic relationships between the frontal cortex and the striatum in this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:43:45