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Titolo:
Co-expression of E-cadherin and alpha-catenin molecules in colorectal cancer
Autore:
Kitagawa, T; Matsumoto, K; Nagafuchi, A; Tsukita, S; Suzuki, H;
Indirizzi:
Yokkaichi Social Insurance Hosp, Dept Surg, Yokkaichi 5100016, Japan Yokkaichi Social Insurance Hosp Yokkaichi Japan 5100016 i 5100016, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 6, volume: 29, anno: 1999,
pagine: 511 - 518
SICI:
0941-1291(1999)29:6<511:COEAAM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; HUMAN ESOPHAGEAL CANCER; HUMAN GASTRIC-CANCER; IMMUNOHISTOCHEMICAL EVALUATION; EXTRACELLULAR-MATRIX; MEDIATED ADHESION; DOWN-REGULATION; TUMOR-CELLS; CARCINOMAS; INVASION;
Keywords:
cadherin; catenin; cell adhesion; colorectal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kitagawa, T Yokkaichi6,ocial Insurance Hosp, Dept Surg, 10-8 Hazuyama, Yokkaichi 510001 Yokkaichi Social Insurance Hosp 10-8 Hazuyama Yokkaichi Japan 5100016
Citazione:
T. Kitagawa et al., "Co-expression of E-cadherin and alpha-catenin molecules in colorectal cancer", SURG TODAY, 29(6), 1999, pp. 511-518

Abstract

Immunohistochemical staining for epithelial (E)-cadherin and alpha-cateninwas performed using frozen sections taken from fresh operative specimens, by the avidin-biotin-peroxidase complex method. Tumors were classified intothree types according to the expression modality. Cancer cells with expression at the cell-cell boundaries were defined as normal; when the expression was positive, but not concentrated at the cell-tell boundaries, they weredefined as cytoplasmic; and when the tumor showed no staining, they were defined as lost, The relationship between these three expression types and the clinicopathological features of colorectal cancer was investigated. In all 50 normal mucosa samples, E-cadherin and alpha-catenin were coexpressed normally. The expression type of E-cadherin and alpha-catenin,vas normal in11 and 13 of the cancer tissue specimens, respectively, cytoplasmic in 26 and 29, respectively, and lost in 13 and 8, respectively. Cytoplasmic or lost expression was observed in cancer demonstrating an advanced clinical stage (E-cadherin, P = 0.0065; alpha-catenin, P = 0.0069), advanced tumor penetration (P = 0.0003, P = 0.0001), undifferentiated tumor histology (P = 0.0196, P = 0.0343), widespread lymph node involvement (P = 0.0204, P = 0.0340), and liver metastasis (P = 0.0063, P = 0.0299), In conclusion, the expression type of E-cadherin is significantly correlated to that of alpha-catenin, and the loss of their expression indicates the metastatic potentiality of colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:32:28