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Titolo:
The in vivo assessment of nimesulide cyclooxygenase-2 selectivity
Autore:
Shah, AA; Murray, FE; Fitzgerald, DJ;
Indirizzi:
Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal CollSurg Ireland Dublin Ireland 2 in Pharmacol, Dublin 2, Ireland Beaumont Hosp, Dept Gastroenterol, Dublin 9, Ireland Beaumont Hosp Dublin Ireland 9 sp, Dept Gastroenterol, Dublin 9, Ireland
Titolo Testata:
RHEUMATOLOGY
, volume: 38, anno: 1999, supplemento:, 1
pagine: 19 - 23
SICI:
1462-0324(199905)38:<19:TIVAON>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN-G/H SYNTHASE-1; ANTI-INFLAMMATORY DRUGS; PEPTIC-ULCER; GASTROINTESTINAL COMPLICATIONS; DOUBLE-BLIND; INHIBITION; ETODOLAC; ACID; INDOMETHACIN;
Keywords:
COX-2; cyclooxygenase; NSAIDs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Fitzgerald, DJ RoyalIrelandurg Ireland, Dept Clin Pharmacol, St Stephens Green, Dublin 2, Royal Coll Surg Ireland St Stephens Green Dublin Ireland 2
Citazione:
A.A. Shah et al., "The in vivo assessment of nimesulide cyclooxygenase-2 selectivity", RHEUMATOLOG, 38, 1999, pp. 19-23

Abstract

In man, nimesulide selectively inhibits cyclooxygenase-2 (COX-2) with little effect on haemostatic function or gastric prostaglandin formation. It causes significantly less gastrointestinal injury than naproxen, but has anti-inflammatory efficacy similar to that of naproxen and other currently available non-steroidal anti-inflammatory drugs. Naproxen suppressed arachidonic-acid-mediated platelet aggregation, reduced serum thromboxane B-2 levels by 98% throughout the treatment period and reduced gastric mucosal prostaglandins (PGE(2) and 6-keto-PGF(1 alpha)) production by an average of 80%. This contrasts with nimesulide: platelet aggregation was not significantly affected, thromboxane B-2 levels were only 29% lower and the gastric mucosal prostaglandins were inhibited in the order of similar to 20%. During the treatment period, both nimesulide and naproxen significantly inhibited COX-2-dependent PGE(2) synthesis in the whole blood; however, naproxen had a lesser effect than nimesulide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:33:35