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Titolo:
Behavioural analysis of the acute and chronic effects of MDMA treatment inthe rat
Autore:
Marston, HM; Reid, ME; Lawrence, JA; Olverman, HJ; Butcher, SP;
Indirizzi:
UnivMidlothian, Dept Pharmacol, Fujisawa Inst Neurosci, Edinburgh EH8 9JZ,Univ Edinburgh Edinburgh Midlothian Scotland EH8 9JZ , Edinburgh EH8 9JZ,
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 144, anno: 1999,
pagine: 67 - 76
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; AMBIENT-TEMPERATURE; METHYLENEDIOXYMETHAMPHETAMINE MDMA; 3,4-METHYLENEDIOXYAMPHETAMINE MDA; ECSTASY MDMA; SEROTONIN; BRAIN; NEUROTOXICITY; MEMORY; HYPERTHERMIA;
Keywords:
MDMA; cognition; DNMTP; paw-reaching; locomotor activity; temperature; 5-HT; citalopram binding; neurotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Marston, HM Univrghinburgh, Dept Pharmacol, Fujisawa Inst Neurosci, 1 George Sq, Edinbu Univ Edinburgh 1 George Sq Edinburgh Midlothian Scotland EH8 9JZ
Citazione:
H.M. Marston et al., "Behavioural analysis of the acute and chronic effects of MDMA treatment inthe rat", PSYCHOPHAR, 144(1), 1999, pp. 67-76

Abstract

Rationale: A variety of animal models have shown MDMA (3,4-methylenedioxymethamphetamine) to be a selective 5-HT neurotoxin, though little is known of the long-term behavioural effects of the pathophysiology. The widespread recreational use of MDMA thus raises concerns over the long-term functionalsequelae in humans. Objective: This study was designed to explore both theacute- and post-treatment consequences of a 3-day neurotoxic exposure to MDMA in the rat, using a variety of behavioural paradigms. Methods: Following training to pretreatment performance criteria, animals were treated twicedaily with ascending doses of MDMA (10, 15, 20 mg/kg) over 3 days. Body temperature, locomotor activity, skilled paw-reaching ability and performanceof the delayed non-match to place (DNMTP) procedure was assessed daily during this period and on an intermittent schedule over the following 16 days. Finally, post mortem biochemical analyses of [H-3] citalopram binding and monoamine levels were performed. Results: During the MDMA treatment period,an acute 5-HT-like syndrome was observed which showed evidence of tolerance. Once drug treatment ceased the syndrome abated completely. During the post-treatment phase, a selective, delay-dependent, deficit in DNMTP performance developed. Post-mortem analysis confirmed reductions in markers of 5-HTfunction, in cortex, hippocampus and striatum, Conclusions: These results confirm that acutely MDMA exposure elicits a classical 5-HT syndrome. In the long-term, exposure results in 5-HT neurotoxicity and a lasting cognitiveimpairment. These results have significant implications for the predictionthat use of MDMA in humans could have deleterious long-term neuropsychological/psychiatric consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:44:26