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Titolo:
The tachykinin NK-1 receptor antagonist, RP-67580, infused into the ventral tegmental area prevents stress-induced analgesia in the formalin test
Autore:
Altier, N; Stewart, J;
Indirizzi:
Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G Concordia Univ Montreal PQ Canada H3G 1M8 hav Neurobiol, Montreal, PQ H3G
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 4, volume: 66, anno: 1999,
pagine: 717 - 721
SICI:
0031-9384(199906)66:4<717:TTNRAR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P INFUSION; NUCLEUS-ACCUMBENS; DOPAMINE NEURONS; NONPEPTIDE ANTAGONIST; SELECTIVE AGONISTS; INDUCED ACTIVATION; NK1 RECEPTOR; TONIC PAIN; RAT-BRAIN; ENKEPHALIN;
Keywords:
substance P; tachykinins; stress; tonic pain; formalin test; neurokinins; dopamine; antinociception;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, J Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, 1455Maisonneuve Concordia Univ 1455 Maisonneuve Blvd W Montreal PQ Canada H3G 1M8
Citazione:
N. Altier e J. Stewart, "The tachykinin NK-1 receptor antagonist, RP-67580, infused into the ventral tegmental area prevents stress-induced analgesia in the formalin test", PHYSL BEHAV, 66(4), 1999, pp. 717-721

Abstract

Substance P (SP) receptors in the ventral tegmental area (VTA) play a critical role in mediating the stress-induced activation of midbrain ascending dopamine (DA) neurons. Interestingly, SP acting in the VTA induces analgesia in the formalin test for tonic pain. Because exposure to stress inhibits pain in this test, we speculated that SP receptors in the VTA might mediatestress-induced analgesia. The present study explored this idea by examining the effect of blocking tachykinin NK-1 receptors in the VTA on footshock stress-induced analgesia in the formalin test. Intra-VTA infusions of the novel tachykinin NK-1 receptor antagonist, RP-67580, prevented this response. This finding suggests that exposure to stress inhibits tonic pain throughthe release of endogenous SP in the VTA. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:01:42