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Titolo:
IBUPROFEN TREATMENT ENHANCES THE SURVIVAL OF MICE FOLLOWING EXPOSURE TO PHOSGENE
Autore:
SCIUTO AM;
Indirizzi:
USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,DIV PATHOPHYSIOL,MCMR-UV-YN,3100 RICKETTS POINT RD ABERDEEN PROVING GROUND MD 21010 USA,MED RES INST CHEM DEF,DIV PHARMACOL,NEUROTOXICOL BRANCH ABERDEEN PROVING GROUND MD 21010
Titolo Testata:
Inhalation toxicology
fascicolo: 4, volume: 9, anno: 1997,
pagine: 389 - 403
SICI:
0895-8378(1997)9:4<389:ITETSO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY-EDEMA; LUNG INJURY; ENDOTOXIC-SHOCK; RAT LUNG; INHALATION; INVITRO; IRON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Sciuto, "IBUPROFEN TREATMENT ENHANCES THE SURVIVAL OF MICE FOLLOWING EXPOSURE TO PHOSGENE", Inhalation toxicology, 9(4), 1997, pp. 389-403

Abstract

The present study was designed to investigate the efficacy of ibuprofen (IBU) administered after a lethal dose of phosgene. Mice were exposed to 32 mg/m(3) phosgene for 20 min and immediately injected with IBU(0, 3, 9, or 15 mg/mouse, ip). Five hours later, a second IBU injection was given but at half the original doses (0, 1.5, 4.5, and 7.5 mg/mouse). These are referred to throughout as the 0/0, 3/1.5, 9/4.5, and 15/7.5 mg IBU/mouse groups. Survival in these groups was determined at12 and 24 h. In mice that died within 12 h, the lungs were removed, and lung wet weights, dry weights, wet/dry weight ratios, malondialdedyde (MDA), and nonprotein sulfhydryls (NPSH) were measured. Survival odds ratios were calculated for each dose at 12 and 24 h. The 12-h survival was 63% for 9/4.5 mg IBU and 82% for the 15/7.5 mg IBU group compared with 25% for saline-treated mice. At 24 h, survival rates were reduced to 19%, 19%, and 6%, respectively. In the 15/7.5 mg IBU group, dry weights, wet/dry weight ratios, and wet weights were significantly lower than in saline-treated mice at 12 h. MDA war lower only for the 9/4.5 mg IBU dose; however, NPSHs were greater across all IBU doses. The survival odds ratio was 5 for the 9/4.5 IBU group at 12 h and 13 forthe 15/7.5 mg IBU group compared with 3.5 for both groups at 24 h. Therefore, IBU treatment increased the survival of mice at 12 h by reducing edema formation, lipid peroxidation, and glutathione depletion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:51:32