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Titolo:
Bowman-Birk inhibitor suppresses production of superoxide anion radicals in differentiated HL-60 cells
Autore:
Ware, JH; Wan, XS; Kennedy, AR;
Indirizzi:
Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA
Titolo Testata:
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
fascicolo: 2, volume: 33, anno: 1999,
pagine: 174 - 177
SICI:
0163-5581(1999)33:2<174:BISPOS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ORAL CARCINOGENESIS; DIMETHYLSULFOXIDE; DIMETHYLHYDRAZINE; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ware, JH 530 Clin Res Bldg,415 Curie Blvd, Philadelphia, PA 19104 USA 530Clin Res Bldg,415 Curie Blvd Philadelphia PA USA 19104 4 USA
Citazione:
J.H. Ware et al., "Bowman-Birk inhibitor suppresses production of superoxide anion radicals in differentiated HL-60 cells", NUTR CANCER, 33(2), 1999, pp. 174-177

Abstract

The Bowman-Birk protease inhibitor (BBI) is a soybean-derived pretense inhibitor with anticarcinogenic and anti-inflammatory properties. BBI has previously been shown to suppress the release of superoxide superoxide anion radicals from purified polymorphonuclear leukocytes. In the present study we evaluated the effect of BBI on the production of superoxide union radicals in differentiated HL-60 cells. HL-60 cells are human lymphocytic cells thatacquire neutrophil-like characteristics when treated with dimethyl sulfoxide or tetradecanoyl phorbol acetate. Superoxide anion radical production bydifferentiated HL-60 cells was measured in the presence of various concentrations of BBI or BBI concentrate, a soybean extract containing high levelsof BBI. BBI was observed to suppress superoxide anion radical production by differentiated HL-60 cells in a dose-dependent manner. Extracts of differentiated HL-60 cells were also observed to produce superoxide anion radicals, but this activity was not affected by the presence of BBI. These resultssuggest that BBI inhibits superoxide anion radical generation in HL-60 cells bur does not act as a simple free radical scavenger.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 01:58:39