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Titolo:
Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3
Autore:
Akao, Y; Nakagawa, Y; Maruyama, W; Takahashi, T; Naoi, M;
Indirizzi:
Inst Appl Biochem, Dept Brain Sci, Gifu 5050116, Japan Inst Appl Biochem Gifu Japan 5050116 Dept Brain Sci, Gifu 5050116, Japan Gifu Int Inst Biotechnol, Gifu, Japan Gifu Int Inst Biotechnol Gifu Japan fu Int Inst Biotechnol, Gifu, Japan Osaka Med Coll, Dept Internal Med 2, Osaka, Japan Osaka Med Coll Osaka Japan Med Coll, Dept Internal Med 2, Osaka, Japan NatlnInst Longev Sci, Dept Basic Gerontol, Biochem & Metab Lab, Aichi, Japa Natl Inst Longev Sci Aichi Japan ntol, Biochem & Metab Lab, Aichi, Japa Aichi Konan Coll, Dept Food & Nutr, Aichi, Japan Aichi Konan Coll Aichi Japan Konan Coll, Dept Food & Nutr, Aichi, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 267, anno: 1999,
pagine: 153 - 156
SICI:
0304-3940(19990604)267:3<153:AIBAEN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROBLASTOMA SH-SY5Y CELLS; DOPAMINERGIC NEUROTOXIN; PARKINSONS-DISEASE; DOWN-REGULATION; PROTEIN; DNA; INCREASES; NEURONS; DEATH;
Keywords:
Parkinson's disease; neurotoxin; N-methyl(R)salsolinol; apoptosis; caspases; dopamine neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Naoi, M Inst Appl Biochem, Dept Brain Sci, Yagi Mem Pk, Gifu 5050116, Japan Inst Appl Biochem Yagi Mem Pk Gifu Japan 5050116 u 5050116, Japan
Citazione:
Y. Akao et al., "Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3", NEUROSCI L, 267(3), 1999, pp. 153-156

Abstract

An endogenous neurotoxin, N-methyl(R)salsolinol, has been proved to be involved in the pathogenesis of Parkinson's disease. Increased level of N-methyl(R)salsolinol in the cerebrospinal fluid and high activity of its synthesizing (R)salsolinol N-methyltransferase in lymphocytes were confirmed in the majority of parkinsonian patients. Recently this neurotoxin was found to induce apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells. In thisstudy, we tried to elucidate the intracellular mechanism of apoptosis induced by N-methyl(R)salsolinol, and proved activation of caspase 3 after incubation with this toxin by Western blot analysis. Further, a caspase 3 inhibitor, acetyl-L-aspartyl-L-glutamyl-L-valyl-L-aspartic aldehyde, prevented the nucleosomal DNA fragmentation completely. These results demonstrate thatcaspase 3 mediates apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, which may cause apoptotic cell death of dopamine neurons in Parkinson's disease. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:32:43