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Titolo:
The use of diffusion tensor imaging in quantifying the effect of dexamethasone on brain tumours
Autore:
Bastin, ME; Delgado, M; Whittle, IR; Cannon, J; Wardlaw, JM;
Indirizzi:
UnivXU,inburgh, Western Gen Hosp, Dept Med Phys & Med Engn, Edinburgh EH4 2 Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU ngn, Edinburgh EH4 2 Univdlothian,h, Western Gen Hosp, Dept Clin Neurosci, Edinburgh EH4 2XU, Mi Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU dinburgh EH4 2XU, Mi
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 10, anno: 1999,
pagine: 1385 - 1391
SICI:
0959-4965(19990514)10:7<1385:TUODTI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE HUMAN STROKE; SELF-DIFFUSION; WATER DIFFUSION; WHITE-MATTER; ANISOTROPY; ECHO; IMAGES; GLIOMAS; MRI;
Keywords:
brain tumours; dexamethasone; diffusion-weighted magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Bastin, ME Univurghnburgh, Western Gen Hosp, Dept Med Phys & Med Engn, Crewe Rd, Edinb Univ Edinburgh Crewe Rd Edinburgh Midlothian Scotland EH4 2XU b
Citazione:
M.E. Bastin et al., "The use of diffusion tensor imaging in quantifying the effect of dexamethasone on brain tumours", NEUROREPORT, 10(7), 1999, pp. 1385-1391

Abstract

THE role of dexamethasone in the treatment of patients with brain tumours remains poorly understood. In this study the self-diffusion parameters of extracellular water within primary intracranial tumours and peritumoural tissue, and their response to dexamethasone, have been measured using MR diffusion tensor imaging. Maps of the mean diffusivity <D> and two measures of diffusion anisotropy were obtained from six patients before, and typically 48-72 h after, commencing dexamethasone treatment. A significant decrease in<D> of either tumour (p<0.02) or oedematous brain (p<0.04) was observed inthree patients. No significant changes were noted in either of the two calculated diffusion anisotropy indices before and after steroid treatment in any of the six patients. Neuro-Report 10:1385-1391 (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 18/09/20 alle ore 17:21:45