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Titolo:
Evidence for increased GDNF signaling in aged sensory and motor neurons
Autore:
Ming, Y; Bergman, E; Edstrom, E; Ulfhake, B;
Indirizzi:
Karolinska,Inst, Dept Neurosci, Chem Neurotransmiss Unit, S-17177 Stockholm Karolinska Inst Stockholm Sweden S-17177 ansmiss Unit, S-17177 Stockholm
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 10, anno: 1999,
pagine: 1529 - 1535
SICI:
0959-4965(19990514)10:7<1529:EFIGSI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE INJURY; NEUROTROPHIC FACTOR; TYROSINE KINASE; SURVIVAL FACTOR; MESSENGER-RNAS; GROWTH-FACTORS; IN-VIVO; RECEPTOR; RET; ALPHA;
Keywords:
dorsal root ganglion; neurotrophins; neurturin; rat; receptors; RT-PCR; spinal cord;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ulfhake, B Karolinska Inst, Dept Neurosci, Chem Neurotransmiss Unit, Doktorsringen 17, Karolinska Inst Doktorsringen 17 Stockholm Sweden S-17177 17,
Citazione:
Y. Ming et al., "Evidence for increased GDNF signaling in aged sensory and motor neurons", NEUROREPORT, 10(7), 1999, pp. 1529-1535

Abstract

SEVERAL lines of evidence suggest that attenuated neurotrophin signaling may account for some of the aging-related phenotypic changes observed in motor and sensory neurons. Glial-derived neurotrophic factor (GDNF) signals through the GFR alpha-1-RET receptor complex and has trophic effects on both primary sensory neurons and, in particular, motoneurons. In this study we provide evidence using RT-PCR that GDNF, but not neurturin, is strongly up-regulated in target muscles (800%) and to a lesser extent also in peripheralsupportive tissues. Results here, and in an earlier study, show that the up-regulation of GDNF in target and supportive tissues parallels an increased neuronal expression of the cognate receptors. Increased GDNF signaling may explain some of the phenotypic characteristics of aging sensory and motoneurons. NeuroReport 10:1529-1535 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:48:27