Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Age-related changes in the modulatory action of gastrin-releasing peptide,neuropeptide Y and sulfated cholecystokinin octapeptide in the proliferation of murine lymphocytes
Autore:
Medina, S; Del Rio, M; De la Cuadra, B; Guayerbas, N; De la Fuente, M;
Indirizzi:
UnivMadrid,tense, Fac Ciencias Biol, Dept Fisiol Anim Biol Anim 2, E-28040Univ Complutense Madrid Spain E-28040 t Fisiol Anim Biol Anim 2, E-28040
Titolo Testata:
NEUROPEPTIDES
fascicolo: 2, volume: 33, anno: 1999,
pagine: 173 - 179
SICI:
0143-4179(199904)33:2<173:ACITMA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; PERITONEAL MACROPHAGE FUNCTIONS; PROTEIN-KINASE-C; SUBSTANCE-P; NERVOUS-SYSTEM; NEUROMEDIN-C; T-CELLS; SOMATOSTATIN; INHIBITION; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M UnivMadrid,tense, Fac Ciencias Biol, Dept Fisiol Anim BiolAnim 2, E-28040 Univ Complutense Madrid Spain E-28040 ol Anim 2, E-28040
Citazione:
S. Medina et al., "Age-related changes in the modulatory action of gastrin-releasing peptide,neuropeptide Y and sulfated cholecystokinin octapeptide in the proliferation of murine lymphocytes", NEUROPEPTID, 33(2), 1999, pp. 173-179

Abstract

Several investigations have suggested that the interactions between the nervous and immune systems are modified with age. The aim of the present workwas to study the effect in vitro of three neuropeptides: gastrin-releasingpeptide (GRP), neuropeptide Y (NPY) and sulfated cholecystokinin octapeptide (CCK-8s) on the spontaneous, as well as on the response to mitogen (concanavalin A), proliferative activity of spleen, thymus and axillary node leukocytes from adult (24 +/- 2 weeks), mature (50 +/- 2 weeks) and old (72 +/- 2 weeks) BALB/c male mice. In control samples, in the absence of neuropeptide, we observed a decreased lymphoproliferation in mature and old mice with respect to the adults in response to mitogen in the three organs studied. As regards, the effect of the neuropeptides, they stimulate the spontaneous proliferation of leukocytes from all locations, in adult animals, an effect that is decreased with ageing tin both mature and old animals). The proliferation in response to mitogen was significantly decreased by the neuropeptides in adults, this effect being progressively reduced with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:19:18