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Titolo:
ANTAGONISM OF SUXAMETHONIUM-INDUCED JAW MUSCLE CONTRACTURE IN RATS
Autore:
SHI Y; STORELLA RJ; KEYKHAH MM; ROSENBERG H;
Indirizzi:
MED COLL PENN & HAHNEMANN UNIV,DEPT ANESTHESIOL,MS 310,BROAD & VINE PHILADELPHIA PA 19102
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 3, volume: 78, anno: 1997,
pagine: 332 - 333
SICI:
0007-0912(1997)78:3<332:AOSJMC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
ANESTHETICS VOLATILE, HALOTHANE; HYPERTHERMIA, MALIGNANT; COMPLICATIONS, MASSETER MUSCLE RIGIDITY; NEUROMUSCULAR BLOCK, SUXAMETHONIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
Y. Shi et al., "ANTAGONISM OF SUXAMETHONIUM-INDUCED JAW MUSCLE CONTRACTURE IN RATS", British Journal of Anaesthesia, 78(3), 1997, pp. 332-333

Abstract

Masseter muscle rigidity (MMR) induced during general anaesthesia by suxamethonium is a clinical problem that may interfere with tracheal intubation. We have investigated the relation between twitch tension and contracture response to suxamethonium in rats. Rats were anaesthetized with 1% halothane (1.35 MAC). Jaw muscle temperature was maintainedat either 37 or 41 degrees C while rectal temperature was kept at 37 degrees C by radiant heat. Twitch tension was produced by nerve stimulation at 0.2 Hz. Rats were pretreated with either a low dose of vecuronium (0.03 mg kg(-1)) or dantrolene (0.8 mg kg(-1)). Thereafter suxamethonium 750 mu g kg(-1) was administrated i.v. Low-dose vecuronium pretreatment significantly (90%) decreased suxamethonium-induced jaw muscle contracture (JMC) with minimal (3%) twitch block during local hyperthermia. Low-dose dantrolene pretreatment also reduced JMC (81% at 37 degrees C and 82% at 41 degrees C) while decreasing twitch by 30% at 37 degrees C and 31% at 41 degrees C. Both vecuronium and dantrolene atdoses that minimally depressed the twitch response antagonized suxamethonium-induced JMC. We speculate that pretreatment with low-dose vecuronium decreases suxamethonium-induced MMR clinically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:21:56