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Titolo:
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans
Autore:
Blelloch, R; Kimble, J;
Indirizzi:
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 ughes Med Inst, Madison, WI 53706 USA Univ Wisconsin, Cell & Mol Biol Program, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 l Biol Program, Madison, WI 53706 USA Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Biochem, Madison, WI 53706 USA Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Med Genet, Madison, WI 53706 USA Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Mol Biol Lab, Madison, WI 53706 USA
Titolo Testata:
NATURE
fascicolo: 6736, volume: 399, anno: 1999,
pagine: 586 - 590
SICI:
0028-0836(19990610)399:6736<586:COOSBA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE-TAGGED SITES; I N-PROTEINASE; PROGELATINASE-A; GENE; SUPERFAMILY; EXPRESSION; ACTIVATION; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kimble, J Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Inst, Madison, WI 53706 USA
Citazione:
R. Blelloch e J. Kimble, "Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans", NATURE, 399(6736), 1999, pp. 586-590

Abstract

The molecular controls governing organ shape are poorly understood. In thenematode Caenorhabditis elegans, the gonad acquires a U-shape by the directed migration of a specialized 'leader' cell, which is located at the tip of the growing gonadal 'arm'(1). The gon-1 gene is essential for gonadal morphogenesis: in gon-1 mutants, no arm elongation occurs and somatic gonadal structures are severely malformed(2). Here we report that gon-1 encodes a secreted protein with a metalloprotease domain and multiple thrombospondin type-1-like repeats. This motif architecture is typical of a small family ofgenes that include bovine procollagen I N-protease (P1NP), which cleaves collagen(3), and murine ADAMTS-1, the expression of which correlates with tumour cell progression(4). We find that gon-1 is expressed in two sites, leader cells and muscle, and that expression in each site has a unique role informing the gonad. We speculate that GON-1 controls morphogenesis by remodelling basement membranes and that regulation of its activity is crucial for achieving organ shape.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:01:42