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Titolo:
Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems
Autore:
Hunger-Glaser, I; Brun, R; Linder, M; Seebeck, T;
Indirizzi:
Univ Bern, Inst Allgemeine Mikrobiol, CH-3012 Bern, Switzerland Univ BernBern Switzerland CH-3012 Mikrobiol, CH-3012 Bern, Switzerland Univ Basel, Swiss Trop Inst, CH-4002 Basel, Switzerland Univ Basel BaselSwitzerland CH-4002 op Inst, CH-4002 Basel, Switzerland
Titolo Testata:
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
fascicolo: 1, volume: 100, anno: 1999,
pagine: 53 - 59
SICI:
0166-6851(19990515)100:1<53:IOSCSH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOSIDE DIPHOSPHATE KINASE; SEMI-DEFINED MEDIUM; SIGNAL-TRANSDUCTION; CULTIVATION; FORMS; THIOKINASES; EUKARYOTES; EQUIPERDUM; ACTIVATION; EVANSI;
Keywords:
Trypanosoma brucei; Leishmania donovani; succinyl CoA synthetase; parasite; chemotherapy; histidine kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Seebeck, T Univndern, Inst Allgemeine Mikrobiol, Baltzerstr 4, CH-3012 Bern, Switzerla Univ Bern Baltzerstr 4 Bern Switzerland CH-3012 ern, Switzerla
Citazione:
I. Hunger-Glaser et al., "Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems", MOL BIOCH P, 100(1), 1999, pp. 53-59

Abstract

Recent drug screenings for new antibacterial drugs directed against histidine phospho-relay signalling pathways in bacteria have resulted in compounds which potently inhibit the histidine kinase activity of bacterial two-component systems. The present study demonstrates that one of these compounds,LY266500, is also a potent inhibitor of histidine phosphorylation in the unicellular eukaryotic parasite Trypanosoma brucei, both in vitro and in whole cells. In vitro, it inhibits histidine phosphorylation of mitochondrial succinyl CoA synthetase. LY26650 does not interfere with the phosphotransfer from the histidine-phosphorylated protein to ADP. In standardized cell culture tests, LY266500 potently inhibits the proliferation of the human pathogens T. brucei rhodesiense and Leishmania donovani. Since the inhibitory activity in vivo is life-cycle stage specific and correlates well with the mitochondrial activity in the different stages, the effect of LY266500 is most likely due to its specific inhibition of the mitochondrial succinyl CoA synthetase. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:08:13