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Titolo:
EVIDENCE THAT FATAL HUMAN INFECTIONS WITH LA-CROSSE VIRUS MAY BE ASSOCIATED WITH A NARROW RANGE OF GENOTYPES
Autore:
HUANG C; THOMPSON WH; KARABATSOS N; GRADY L; CAMPBELL WP;
Indirizzi:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR,POB 509 ALBANY NY 12201 CTR DIS CONTROL & PREVENT FT COLLINS CO 80522
Titolo Testata:
Virus research
fascicolo: 2, volume: 48, anno: 1997,
pagine: 143 - 148
SICI:
0168-1702(1997)48:2<143:ETFHIW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAL-RNA SEGMENT; CALIFORNIA SEROGROUP VIRUSES; SNOWSHOE HARE BUNYAVIRUS; LACROSSE VIRUS; MESSENGER-RNA; PROTEIN; GENOME; IDENTIFICATION; VIRULENCE; SEQUENCE;
Keywords:
LA CROSSE VIRUS; MOSQUITO ISOLATES; GENOTYPE; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Huang et al., "EVIDENCE THAT FATAL HUMAN INFECTIONS WITH LA-CROSSE VIRUS MAY BE ASSOCIATED WITH A NARROW RANGE OF GENOTYPES", Virus research, 48(2), 1997, pp. 143-148

Abstract

La Crosse (LAC) virus belongs to the California (CAL) serogroup of the genus Bunyavirus lu, family Bunyaviridae. It is considered one of the most important mosquito-borne pathogens in North America, especiallyin the upper Mid-West, where it is associated with encephalitis during the time of year when mosquitoes are active. Infections occur most frequently in children and young adults and, while most cases are resolved after a period of intense illness, a small fraction (< 1%) are fatal. At present there have only been three isolates of LAC virus from humans, all made from brain tissue postmortem. The cases yielding viruses are separated chronologically by 33 years and geographically from Minnesota/Wisconsin (1960, 1978) to Missouri (1993). The M RNA sequenceof the first two isolates was previously reported. The present study extends the observations to the isolate from the 1993 case and includes several mosquito isolates as well. A comparison of the M RNAs of these viruses shows that for the human isolates both nucleotide sequence and the deduced amino-acid sequence of the encoded proteins are highlyconserved, showing a maximum variation of only 0.91% and 0.69%, respectively. This high degree of conservation over time and space leads tothe hypothesis that human infections with this particular genotype ofLAC virus are those most likely to have a fatal outcome. It is also shown that a virus with this genotype could be found circulating in mosquitoes in an area more or less intermediate between the locations of the first and second fatal cases. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:11:03