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Titolo:
Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPAR gamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys
Autore:
Hotta, K; Bodkin, NL; Gustafson, TA; Yoshioka, S; Ortmeyer, HK; Hansen, BC;
Indirizzi:
Univ Maryland, Sch Med, Obes & Diabet Res Ctr, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 bet Res Ctr, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 ept Physiol, Baltimore, MD 21201 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 5, volume: 54, anno: 1999,
pagine: B183 - B188
SICI:
1079-5006(199905)54:5<B183:AATMEO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; ADIPOCYTE PRECURSOR CELLS; BINDING-PROTEIN-ALPHA; MESSENGER-RNA LEVELS; GENE-EXPRESSION; ANATOMIC SITE; TRANSCRIPTION FACTOR; MOLECULAR-CLONING; C/EBP-ALPHA; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hansen, BC Univ Maryland, Sch Med, Obes & Diabet Res Ctr, 10 S Pine St,MSTF Room 6-00, Univ Maryland 10 S Pine St,MSTF Room 6-00 Baltimore MD USA 21201
Citazione:
K. Hotta et al., "Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPAR gamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys", J GERONT A, 54(5), 1999, pp. B183-B188

Abstract

Aging has been shown to have an effect on the capacity to differentiate preadipocytes and on the expression of some genes expressed in adipose tissue. The mRNA levels of adipocyte differentiation-related genes were examined in rhesus monkeys (Macaca Mulatta) ranging in age from 7 to 30 years. The effect of aging on the expression of peroxisome proliferator activated receptor gamma (PPAR gamma) adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein I (ADD1/SREBP1) CCAAT/enhancer binding protein alpha (C/EBP alpha) lipoprotein lipase (LPL) GLUT4 glucose transporter and adipsin were examined by slot blot analysis. Significant inverse correlations were observed between age and the mRNA levels of PPAR gamma, ADD1/SREBP1, LPL, and GLUT4. The coordinate downregulation of these genes may be linked to the declining fat mass of senescent animals. There was no correlation between age and the mRNA levels of adipsin. The mRNA levels of these genes were not correlated to body weight or fasting plasma insulin. These findings indicate that aging may have an effect on the adipocyte differentiation program and this effect appears to be gene specific.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:52:40