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Titolo:
Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions
Autore:
Liaw, KL; Glass, AG; Manos, MM; Greer, CE; Scott, DR; Sherman, M; Burk, RD; Kurman, RJ; Wacholder, S; Rush, BB; Cadell, DM; Lawler, P; Tabor, D; Schiffman, M;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 Epidemiol & Genet, NIH, Bethesda, MD 20892 USA Kaiser Permanente, Portland, OR USA Kaiser Permanente Portland OR USAKaiser Permanente, Portland, OR USA Cetus Corp, Emeryville, CA 94608 USA Cetus Corp Emeryville CA USA 94608Cetus Corp, Emeryville, CA 94608 USA Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Albert Einstein Coll Med, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Coll Med, Bronx, NY 10467 USA Westal Inc, Rockville, MD USA Westal Inc Rockville MD USAWestal Inc, Rockville, MD USA
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 11, volume: 91, anno: 1999,
pagine: 954 - 960
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTION; RISK; NEOPLASIA; DETERMINANTS; PREVALENCE; GENOTYPES; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Schiffman, M NCI,20892Canc Epidemiol & Genet, NIH, Execut Plaza S,Rm 7066,Bethesda, MD NCI Execut Plaza S,Rm 7066 Bethesda MD USA 20892 Bethesda, MD
Citazione:
K.L. Liaw et al., "Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions", J NAT CANC, 91(11), 1999, pp. 954-960

Abstract

Background: Human papillomavirus (HPV) infection has been strongly associated with cervical carcinoma and its cytologic precursors, squamous intraepithelial lesions (SIL). We investigated the risk of SIL prospectively following polymerase chain reaction (PCR)based DNA testing for a wide range of genital HPV types in a cohort of initially cytologically normal women, to clarify the role of HPV in the etiology of SIL. Methods: Starting in April 1989, 17 654 women who were receiving routine cytologic screening at Kaiser Permanente (Portland, OR) were followed for the development of incident SIL. During follow-up, 380 incident case patients and 1037 matched control subjects were eligible for this nested case-control study. Cervical lavages collected at enrollment and, later, at the time of case diagnosis (or the corresponding time for selection of central subjects) were tested for HPV DNA using a PCR-based method. The data were analyzed as contingency tables with two-sided P values or, for multivariable analyses, using odds ratios (ORs) with 95% confidence intervals (CLs). Results: In comparison with initially HPV-negative women, women who tested positive for HPV DNA at enrollment were3.8 times (95% CI = 2.6-5.5) more likely to have low-grade SIL subsequently diagnosed for the first time during follow-up and 12.7 times more likely (95% CI = 6.2-25.9) to develop high-grade SIL. At the time of diagnosis, the cross-sectional association of HPV DNA and SIL was extremely strong (OR =44.4 and 95% CI = 24.2-81.5 for low-grade SIL and OR = 67.1 and 95% CI = 19.3-233.7 for high-grade SIL). HPV16 was the virus type most predictive of SIL, even low-grade SIL. Conclusions: These findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia,Furthermore, they support HPV vaccine research to prevent cervical cancer and efforts to develop HPV DNA diagnostic tests.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 09:18:17