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Titolo:
Modulation of murine lymphocyte responsiveness by the saliva of Rhodnius prolixus (Hemiptera : Reduviidae)
Autore:
Kalvachova, P; Hribalova, V; Kodym, P; Volf, P;
Indirizzi:
Charles Univ, Dept Parasitol, CR-12844 Prague 2, Czech Republic Charles Univ Prague Czech Republic 2 , CR-12844 Prague 2, Czech Republic Natl Inst Hlth, Prague 10042 10, Czech Republic Natl Inst Hlth Prague Czech Republic 10042 10 e 10042 10, Czech Republic
Titolo Testata:
JOURNAL OF MEDICAL ENTOMOLOGY
fascicolo: 3, volume: 36, anno: 1999,
pagine: 341 - 344
SICI:
0022-2585(199905)36:3<341:MOMLRB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLY LUTZOMYIA-LONGIPALPIS; IMMUNE-RESPONSES; GLAND EXTRACTS; VECTOR SALIVA; IN-VITRO; MACROPHAGES; SIMULIIDAE; ARTHROPODS; ANTIGENS; IXODIDAE;
Keywords:
Rhodnius; Triatoma; Trypanosoma cruzi; salivary glands; immunomodulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kalvachova, P Charles Univ, Dept Parasitol, Vinicna 7, CR-12844 Prague 2, Czech Republic Charles Univ Vinicna 7 Prague Czech Republic 2 ech Republic
Citazione:
P. Kalvachova et al., "Modulation of murine lymphocyte responsiveness by the saliva of Rhodnius prolixus (Hemiptera : Reduviidae)", J MED ENT, 36(3), 1999, pp. 341-344

Abstract

Incorporation of H-3-thymidine by splenic lymphocytes was studied in CBA mice that were bitten by the triatomine bug Rhodnius prolixus (Stal) 14, 7, 4, and 2 d before lymphocyte isolation, respectively. In bitten mice, both spontaneous and mitogen-induced proliferative responses were reduced. The most pronounced effect was observed 4 d after exposure when lymphocytes weresignificantly suppressed in proliferative response to the mitogens concanavalin A, phytohemagglutinin, and bacterial lipopolysaccharide. The maximum inhibition caused an 85% reduction of proliferation and was observed in phytohemagglutinin-stimulated cell cultures. The immunosuppressive effect was caused neither by stress nor by an nonspecific cytotoxic effect of R. prolixus saliva. The described immunosuppressive activity of saliva could aid insuccessful repeated feedings of R, prolixus on the same host and possibly could play a role in transmission of Trypanosoma cruzi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:16:49