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Titolo:
Colonic endocrine cells in patients with familial amyloidotic polyneuropathy
Autore:
Anan, I; El-Salhy, M; Ando, Y; Nyhlin, N; Terazaki, H; Sakashita, N; Suhr, O;
Indirizzi:
UmeanUniv Hosp, Dept Med, Sect Gastroenterol & Hepatol, S-90185 Umea, Swede Umea Univ Hosp Umea Sweden S-90185 nterol & Hepatol, S-90185 Umea, Swede Kumamoto Univ Hosp, Dept Pathol 2, Kumamoto, Japan Kumamoto Univ Hosp Kumamoto Japan Hosp, Dept Pathol 2, Kumamoto, Japan Kumamoto Univ Hosp, Dept Internal Med 1, Kumamoto, Japan Kumamoto Univ Hosp Kumamoto Japan Dept Internal Med 1, Kumamoto, Japan
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 5, volume: 245, anno: 1999,
pagine: 469 - 473
SICI:
0954-6820(199905)245:5<469:CECIPW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSTHYRETIN; DYSFUNCTION;
Keywords:
colon; familial amyloidosis; immunohistochemistry; peptide YY; serotonin; somatostatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: El-Salhy, M UmeanUniv Hosp, Dept Med, Sect Gastroenterol & Hepatol, S-90185 Umea, Swede Umea Univ Hosp Umea Sweden S-90185 atol, S-90185 Umea, Swede
Citazione:
I. Anan et al., "Colonic endocrine cells in patients with familial amyloidotic polyneuropathy", J INTERN M, 245(5), 1999, pp. 469-473

Abstract

Objective, To establish whether the endocrine cell number is affected in the colon in Japanese FAP patients. Setting, Department of Medicine, Umea University Hospital and Department of Internal Medicine and Pathology, University Hospital, Kumamoto, Japan. . Subjects:Autopsy colon tissue specimens from 11 FAP patients and nine controls as well as 12 control biopsy specimens were included in the study. Measurements, Endocrine cells in the colon were detected by immunohistochemistry and quantified by computerized image analysis. Results, The autopsy material showed a slight autolysis. Neither enteroglucagon nor pancreatic polypeptide positive cells could be detected in the autopsy material, but were present in biopsy material. There was no statistical difference between autopsy and biopsy specimens regarding the number of peptide YY (PYY), somatostatin and serotonin cells. No significant differences were noted in PYY, somatostatin and serotonin immunoreactive cells in FAP patients compared to autopsy controls, though PW cells tended to be decreased and serotonin and somatostatin cells tended to be increased in FAP patients. Conclusion, The difference between the Swedish and Japanese patients in the endocrine cell content points to the possibility of involvement of other factors than the endocrine cell depletion of the colon might be involved inthe pathogenesis of gastrointestinal dysfunction in FAP, The tendency of PW to decrease in Japanese FAP might contribute to the development of diarrhoea in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:08:22