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Titolo:
The survival and well-being of patients treated for Cushing's syndrome
Autore:
Pikkarainen, L; Sane, T; Reunanen, A;
Indirizzi:
Univ Helsinki Hosp, Dept Med, Div Endocrinol, FIN-00290 Helsinki, Finland Univ Helsinki Hosp Helsinki Finland FIN-00290 IN-00290 Helsinki, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 5, volume: 245, anno: 1999,
pagine: 463 - 468
SICI:
0954-6820(199905)245:5<463:TSAWOP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE DEFICIENCY; DISEASE; SURGERY; ADULTS;
Keywords:
Cushing's syndrome; pituitary; survival; transsphenoidal pituitary surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Sane, T UnivHelsinki, Hosp, Dept Med, Div Endocrinol, Haartmanninkatu 4, FIN-00290 Univ Helsinki Hosp Haartmanninkatu 4 Helsinki Finland FIN-00290 0
Citazione:
L. Pikkarainen et al., "The survival and well-being of patients treated for Cushing's syndrome", J INTERN M, 245(5), 1999, pp. 463-468

Abstract

Objective, The main aim of the study was to evaluate the survival, well-being and working capacity of patients treated for Gushing's syndrome,Design. The study was carried out by retrospectively analysing patient records from years 1981-94. Follow-up time was extended from the time of diagnosis to the end of 1996, A questionnaire dealing with symptoms prior to andafter therapy, and the quality of life estimated on a Visual Analogue Scale (VAS) was sent to all surviving patients,Setting. The study was performed in a university hospital. Main outcome measures. Survival, subjective wellbeing, working capacity before and after treatment and disappearance of symptoms after treatment of Gushing's syndrome. Results. During the follow-up time 10 patients died out of a total of 74. The overall standardized mortality ratio (SMR) was 168% (95% GI 81-309%). The SMR of patients with pituitary disease was 267% (89-525%), and in patients with adrenal adenoma it was 135% (16-489%). Forty-six per cent of the surviving patients stated that they felt fully recovered from the disease, but the proportion of patients having persisting symptoms after treatment wasalso noteworthy. The mean VAS score (range 0-100) was 19 (SD 14) before treatment and 82 (SD 18) after treatment (P < 0.001). After treatment, 81% ofthe patients were able to return to work, 11% retired because of disability, 5% retired because of age and 3% were on sick-leave at the time of answering the questionnaire. During the follow-up time, 42% of the patients withpituitary disease suffered a relapse. However, the effect of the relapse on well-being was not significant. Conclusions. The mortality risk of patients treated for Gushing's disease was not significantly increased compared with that of the general population. Many symptoms persisted even years after therapy. After clinical recovery, working ability was not always regained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 13:48:16