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Titolo:
Novel four-drug salvage treatment regimens after failure of a human immunodeficiency virus type 1 protease inhibitor-containing regimen: Antiviral activity and correlation of baseline phenotypic drug susceptibility with virologic outcome
Autore:
Deeks, SG; Hellmann, NS; Grant, RM; Parkin, NT; Petropoulos, CJ; Becker, M; Symonds, W; Chesney, M; Volberding, PA;
Indirizzi:
Univo,alif San Francisco, San Francisco Gen Hosp, ViroLog Inc, San Francisc Univ Calif San Francisco San Francisco CA USA 94110 Log Inc, San Francisc Gladstone Inst Virol & Immunol, San Francisco, CA USA Gladstone Inst Virol& Immunol San Francisco CA USA an Francisco, CA USA Agouron Pharmaceut, La Jolla, CA USA Agouron Pharmaceut La Jolla CA USAAgouron Pharmaceut, La Jolla, CA USA Glaxo Wellcome, Res Triangle Pk, NC USA Glaxo Wellcome Res Triangle Pk NCUSA Wellcome, Res Triangle Pk, NC USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 6, volume: 179, anno: 1999,
pagine: 1375 - 1381
SICI:
0022-1899(199906)179:6<1375:NFSTRA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE; HIV-INFECTION; RESISTANCE; NEVIRAPINE; INDINAVIR; RITONAVIR; ADULTS; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Deeks, SG UnivAve,if San Francisco, San Francisco Gen Hosp, ViroLog Inc, 995 Potrero Univ Calif San Francisco 995 Potrero Ave San Francisco CA USA 94110
Citazione:
S.G. Deeks et al., "Novel four-drug salvage treatment regimens after failure of a human immunodeficiency virus type 1 protease inhibitor-containing regimen: Antiviral activity and correlation of baseline phenotypic drug susceptibility with virologic outcome", J INFEC DIS, 179(6), 1999, pp. 1375-1381

Abstract

Twenty human immunodeficiency virus-infected patients experiencing virologic failure of an indinavir- or ritonavir-containing treatment regimen were evaluated in a prospective, open-label study. Subjects received nelfinavir,saquinavir, abacavir, and either another nucleoside analog (n = 10) or nevirapine (n = 10), Patients treated with the nevirapine-containing regimen experienced significantly greater virologic suppression at week 24 than those not treated with nevirapine (P =.04), Baseline phenotypic drug susceptibility was strongly correlated with outcome in both treatment arms. Subjects with baseline virus phenotypically sensitive to 2 or 3 drugs in the salvageregimen experienced significantly greater virus load suppression than those with baseline virus sensitive to 0 or 1 drug (median week-24 change = -2.24 log and -0.35 log, respectively; P =.01), In conclusion, non-nucleoside reverse transcriptase inhibitors may represent a potent drug in salvage therapy regimens after failure of an indinavir or ritonavir regimen. Phenotypic resistance testing may provide a useful tool for selecting more effectivesalvage regimens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 15:27:19