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Titolo:
NMDA receptor NR1 and NR2A/B subunit expression in trigeminal neurons during early postnatal development
Autore:
Turman, JE; Ajdari, J; Chandler, SH;
Indirizzi:
Univ So Calif, Dept Biokinesiol & Phys Therapy, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Therapy, Los Angeles, CA 90033 USA Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 409, anno: 1999,
pagine: 237 - 249
SICI:
0021-9967(19990628)409:2<237:NRNANS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; RAT-BRAIN; GUINEA-PIG; SUBCELLULAR-DISTRIBUTION; MESENCEPHALIC NUCLEUS; VISUAL-CORTEX; MOTOR-NEURONS; IN-VITRO; AFFERENT; LOCALIZATION;
Keywords:
glutamate; immunohistochemistry; oral; jaw; suckling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Turman, JE UnivLos Calif, Dept Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP-155, Univ So Calif 1540 E Alcazar St,CHP-155 Los Angeles CA USA 90033
Citazione:
J.E. Turman et al., "NMDA receptor NR1 and NR2A/B subunit expression in trigeminal neurons during early postnatal development", J COMP NEUR, 409(2), 1999, pp. 237-249

Abstract

Trigeminal motoneurons (Mo5), mesencephalic trigeminal neurons (Me5), and supratrigeminal (Su5) and intertrigeminal (15) neurons are important constituents of the neural circuitry responsible for jaw movements observed during ingestive behaviors. In addition, in adult animals, N-methyl-D-aspartate (NMDA) receptors are a critical component of the brainstem circuitry responsible for reflex- and centrally activated jaw movements. However, little isknown about the expression of this receptor in circuitry used to produce neonatal jaw movements. Receptor immunohistochemistry was used to describe changes in the expression of NMDA NR1 and NR2A/B receptor subunits in Mo5, Me5, Su5, and 15 neurons during postnatal development. Rats at postnatal days (P) 1, 3, 8, 15-16, 21-24, and 28-35 were used. An affinity-purified polyclonal antibody against the NR1 subunit and an affinity-purified polyclonalantibody that recognizes both NR2A and 2B subunits were used to depict theexpression of these subunits. In Mo5, immunoreactivity was noted for both antibodies throughout the time frame sampled. NR1 expression in Me5 neuronsemerged at P1. NR2A/B expression emerged at P3 in caudal and middle regions of Me5 and at P8 for rostral regions of the nucleus. NR1 immunoreactivitywas present at P1 for neurons in 15 and at P3 for neurons in the Su5 region. NR2A/B subunit expression in Su5 and 15 neurons emerged at P8. These results provide evidence for NMDA receptor subunits in neonatal trigeminal neurons used in oral-motor circuitry and suggest a role for the NMDA receptor in synaptogenesis associated with these neurons during postnatal development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:56:15