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Titolo:
Effect of targeted expression of clusterin in photoreceptor cells on retinal development and differentiation
Autore:
Jomary, C; Chatelain, G; Michel, D; Weston, A; Neal, MJ; Jones, SE;
Indirizzi:
StaThomas Hosp, Rayne Inst, GKT,Dept Pharmacol, British Retinitis Pigmentos St Thomas Hosp London England SE1 7EH macol, British Retinitis Pigmentos Ecoleyonrmale Super Lyon, CNRS, UMR49, Lab Biol Mol & Cellulaire, F-69364 L Ecole Normale Super Lyon Lyon France 07 Biol Mol & Cellulaire, F-69364 L Stndhomas Hosp, Rayne Inst, GKT, Ophthalmol Res Unit, London SE1 7EH, Engla St Thomas Hosp London England SE1 7EH ol Res Unit, London SE1 7EH, Engla
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 10, volume: 112, anno: 1999,
pagine: 1455 - 1464
SICI:
0021-9533(199905)112:10<1455:EOTEOC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATED GLYCOPROTEIN-2 CLUSTERIN; BINDING PROTEIN IRBP; MESSENGER-RNA; RETINITIS-PIGMENTOSA; GENE-EXPRESSION; TRANSGENIC MICE; IN-VITRO; APOLIPOPROTEIN-J/CLUSTERIN; MULTIFUNCTIONAL PROTEIN; MOUSE RETINAS;
Keywords:
clusterin; apoptosis; retina; neurodegeneration; transgenic animal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Jomary, C StaThomas Hosp, Rayne Inst, GKT,Dept Pharmacol, British Retinitis Pigmentos St Thomas Hosp London England SE1 7EH tish Retinitis Pigmentos
Citazione:
C. Jomary et al., "Effect of targeted expression of clusterin in photoreceptor cells on retinal development and differentiation", J CELL SCI, 112(10), 1999, pp. 1455-1464

Abstract

Clusterin expression is increased in tissues undergoing apoptosis, including neurodegenerative retina, but the causal relationships remain to be clarified. To test the hypothesis that overexpression of clusterin could induceapoptosis in neurons, transgenic mice were generated in which rat clusterin transgene was expressed in photoreceptor cells under the transcriptional control of the human interphotoreceptor retinoid-binding protein (IRBP) promoter, Photoreceptor cell death in the resulting transgenic mice was examined by histology and TUNEL techniques. The expression of the clusterin transgene was confirmed by in situ hybridization in the photoreceptor cells, andresults in a complex pattern of clusterin protein distribution in the retina. A reduction in apoptotic staining in the transgenic retinas was observed from birth to postnatal day 15. These results suggest that clusterin is not causally involved in apoptotic mechanisms of photoreceptor cell death, but may relate to cytoprotective functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:41:47