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Titolo:
One-dimensional diffusion of proteins along DNA - Its biological and chemical significance revealed by single-molecule measurements
Autore:
Shimamoto, N;
Indirizzi:
Natl Inst Genet, Struct Biol Ctr, Mishima, Shizuoka 4118540, Japan Natl Inst Genet Mishima Shizuoka Japan 4118540 a, Shizuoka 4118540, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 22, volume: 274, anno: 1999,
pagine: 15293 - 15296
SICI:
0021-9258(19990528)274:22<15293:ODOPAD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRESSOR-OPERATOR INTERACTION; COLI RNA-POLYMERASE; RESTRICTION-ENDONUCLEASE ECORI; IRRADIATED ESCHERICHIA-COLI; INITIATED EXCISION REPAIR; LAC REPRESSOR; LINEAR DIFFUSION; FACILITATED DIFFUSION; ASSOCIATION KINETICS; DRIVEN MECHANISMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Shimamoto, N Natl Inst Genet, Struct Biol Ctr, Mishima, Shizuoka 4118540, Japan Natl Inst Genet Mishima Shizuoka Japan 4118540 118540, Japan
Citazione:
N. Shimamoto, "One-dimensional diffusion of proteins along DNA - Its biological and chemical significance revealed by single-molecule measurements", J BIOL CHEM, 274(22), 1999, pp. 15293-15296

Abstract

Evidence for sliding of proteins along DNA has been provided by many kinetic studies, but single-molecule-based measurements have uncovered distinct problems, the solutions of which may lead us to an understanding of new mechanisms for gene regulation. Furthermore, they reveal a deep problem lying between chemistry and physics regarding the seemingly simple binding between DNA and protein. Single-molecule dynamics provides a tool to solve this problem without prejudgments or unsound assumptions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:11:17