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Titolo:
Combined effects of probucol and bezafibrate on lipoprotein metabolism andliver cholesteryl ester transfer protein mRNA in cholesterol-fed rabbits
Autore:
Ou, JF; Saku, K; Jimi, S; Liao, YL; Ohta, T; Zhang, B; Arakawa, K;
Indirizzi:
Fukuoka Univ, Sch Med, Dept Internal Med, Jonanku, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 Med, Jonanku, Fukuoka 8140180, Japan Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 , Dept Pathol, Fukuoka 8140180, Japan Univ Ryukyus, Fac Med, Dept Pediat, Okinawa, Japan Univ Ryukyus Okinawa Japan yukyus, Fac Med, Dept Pediat, Okinawa, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 6, volume: 63, anno: 1999,
pagine: 471 - 477
SICI:
0047-1828(199906)63:6<471:CEOPAB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; HERITABLE HYPERLIPIDEMIC RABBIT; APOLIPOPROTEIN-A-I; MESSENGER-RNA; FAMILIAL HYPERCHOLESTEROLEMIA; CORONARY ANGIOPLASTY; ATHEROSCLEROSIS; PROGRESSION; MECHANISM; THERAPY;
Keywords:
bezafibrate; cholesteryl ester transfer protein; hypercholesterolemia; lipids; lipoproteins; mRNA; probucol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Saku, K Fukuoka Univ, Sch Med, Dept Internal Med, Jonanku, 45-1-7 Nanakuma, Fukuoka Fukuoka Univ 45-1-7 Nanakuma Fukuoka Japan 8140180 akuma, Fukuoka
Citazione:
J.F. Ou et al., "Combined effects of probucol and bezafibrate on lipoprotein metabolism andliver cholesteryl ester transfer protein mRNA in cholesterol-fed rabbits", JPN CIRC J, 63(6), 1999, pp. 471-477

Abstract

Probucol decreases and bezafibrate increases plasma high density lipoprotein-cholesterol (HDL-C) levels in humans. This study was performed to determine whether the HDL-C-lowering effects of probucol could be reversed by treatment with bezafibrate in hypercholesterolemic rabbits. Forty-nine normolipidemic Japanese White rabbits were divided into 5 groups [group 1: normal chow; group 2: 0.2% cholesterol (Ch) diet; group 3: 0.2% Ch and 1% probucoldiet; group 4: 0.2% Ch and 1% bezafibrate diet; group 5: 0.2% Ch and 1% probucol plus 1% bezafibrate diet] and treated for 8 weeks. Plasma lipids, cholesteryl ester transfer protein (CETP) activity in the lipoprotein-deficient plasma fraction, CETP mRNA in liver tissue and plasma drug concentrations were investigated. Serum total cholesterol (TC) increased after the rabbits in groups 2, 3, 4 and 5 were fed Ch, but overall, no significant differences were observed in serum TC and triglyceride (TG) among these groups. Serum HDL-C levels increased (p<0.01) in the bezafibrate-treated group, but asignificant (p<0.05) reduction in HDL-C was observed in both the Ch + probucol (group 3) and Ch + probucol plus bezafibrate (group 5) groups; no significant difference was observed between groups 3 and 5. Significant correlation (p<0.01) was found between serum low density lipoprotein cholesterol (LDL-C) levels and plasma probucol concentrations in groups 3 and 5, but no correlation was found between plasma concentrations of probucol/bezafibrateand serum HDL-C levels. CETP activity in the lipoprotein-deficient plasma fraction increased in the Ch-, Ch + probucol-, and Ch + probucol and bezafibrate-fed groups (groups 2, 3 and 5, respectively), whereas a significant reduction in this activity was observed in the Ch + bezafibrate-fed group (group 4). An analysis of covariance showed that the CETP activity responded more sensitively to drug treatment than did the serum HDL-C level. CETP mRNA in liver tissue was assessed by Northern blotting at 8 weeks, but no changes were observed among the 5 groups. Probucol decreased and bezafibrate increased serum HDL-C levels, through CETP activity without affecting liver CETP mRNA levels, and the decrease in HDL-C levels produced by probucol could not be reversed by bezafibrate.

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Documento generato il 10/07/20 alle ore 08:13:51