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Titolo:
Serum concentrations of squamous cell carcinoma antigen in patients with vulvar intraepithelial neoplasia and vulvar cancer
Autore:
Hefler, L; Obermair, A; Tempfer, C; van Houte, M; Maenner, G; Reinthaller, A; Leodolter, S; Kainz, C;
Indirizzi:
Univ Vienna, Sch Med, Dept Obstet & Gynaecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 tet & Gynaecol, A-1090 Vienna, Austria Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 tet & Gynecol, Houston, TX 77030 USA Univ Vienna, Sch Med, Dept Med Lab Diagnost, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 d Lab Diagnost, A-1090 Vienna, Austria
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 3, volume: 84, anno: 1999,
pagine: 299 - 303
SICI:
0020-7136(19990621)84:3<299:SCOSCC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; CERVICAL-CARCINOMA; OVARIAN-CARCINOMA; TUMOR-MARKER; DISEASE; SCC; EXPRESSION; PREDICTION; RECURRENCE; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hefler, L Univ0Vienna, Sch Med, Dept Obstet & Gynaecol, Wahringer Gurtel 18-20, A-109 Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 A-109
Citazione:
L. Hefler et al., "Serum concentrations of squamous cell carcinoma antigen in patients with vulvar intraepithelial neoplasia and vulvar cancer", INT J CANC, 84(3), 1999, pp. 299-303

Abstract

Our aim was to evaluate whether serum concentrations of squamous cell carcinoma antigen (SCC-Ag) are an independent prognostic factor in patients with vulvar cancer. We measured SCC-Ag in pretreatment serum samples of 55 patients with squamous cell vulvar cancer, 30 patients with vulvar intraepithelial neoplasia (VIN) grade III and 50 healthy female controls. The results were compared with clinical data. Median serum concentrations of SCC-Ag in healthy female controls, patients with VIN III, and patients with invasive vulvar cancer were 0.5 (range 0.1 to 3.8) ng/mL, 0.5 (range 0 to 4.1) ng/mLand 1.6 (range 0.3 to 65) ng/mL, respectively (Mann-Whitney U test, P< 0.001). The 75% quantile of serum concentrations of SCC-Ag in patients with vulvar cancer was defined as cut-off level. Elevated pretreatment serum concentrations of SCC-Ag were significantly correlated with a shorter disease-free and overall survival (log-rank test, p=0.002; and p<0.001, respectively). A multivariate Cox regression model showed that serum concentrations of SCC-Ag are a prognostic factor of disease-free and overall survival independent of tumour stage (multivariate Cox regression model, p=0.03; and p=0.048, respectively), pre-treatment serum concentrations of SCC-Ag were not correlated with tumour stage, histological grade and patients' age. In summary,our data indicate that serum concentrations of SCC-Ag may be an additionalindependent prognostic factor of disease-free and overall survival in patients with vulvar cancer. Int. J. Cancer (Pred. Oncol) 84:299-303, 1999. (C)1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:04:09