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Titolo:
IL-7 receptor alpha(+) CD3(-) cells in the embryonic intestine induces theorganizing center of Peyer's patches
Autore:
Yoshida, H; Honda, K; Shinkura, R; Adachi, S; Nishikawa, S; Maki, K; Ikuta, K; Nishikawa, S;
Indirizzi:
Kyoto Univ, Fac Med, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Mol Genet, Sakyo Ku, Kyoto 6068507, Japan Kyotoanniv, Fac Med, Dept Biol Mol, Inst Genet,Sakyo Ku, Kyoto 6068507, Jap Kyoto Univ Kyoto Japan 6068507 , Inst Genet,Sakyo Ku, Kyoto 6068507, Jap Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Med Chem, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 5, volume: 11, anno: 1999,
pagine: 643 - 655
SICI:
0953-8178(199905)11:5<643:IRACCI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL LYMPHOID ORGANS; TUMOR-NECROSIS-FACTOR; BETA-DEFICIENT MICE; INTERLEUKIN-7 RECEPTOR; B-CELL; C-KIT; LYMPHOTOXIN-BETA; GAMMA CHAIN; ABNORMAL-DEVELOPMENT; EXPRESSION;
Keywords:
development; IL-7R alpha; lymphotoxin; organizing center; Peyer's patch;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshida, H KyotooUniv, Fac Med, Dept Mol Genet, Sakyo Ku, Syogoin Kawaharacho 53, Kyot Kyoto Univ Syogoin Kawaharacho 53 Kyoto Japan 6068507 53, Kyot
Citazione:
H. Yoshida et al., "IL-7 receptor alpha(+) CD3(-) cells in the embryonic intestine induces theorganizing center of Peyer's patches", INT IMMUNOL, 11(5), 1999, pp. 643-655

Abstract

Peyer's patch (PP) organogenesis proceeds through three histologically distinct steps: formation of organizing centers expressing VCAM-1 and ICAM-1 in segregated regions of the intestine at 15.5 days post-coitus (d.p.c. ) (step I), accumulation of blood cells expressing different sets of surface markers to this region at 16.5-17.0 d.p.c. (step II), and entry of CD3(+) and B220(+) lymphocytes just before birth (step III). PP formation of both 117ra(-/-) and Lta(-/-) mice is impaired from step I, suggesting involvement ofthe two molecules at the same timing in PP organogenesis. Expression of lymphotoxin (LT) alpha and LT beta in IL-7 receptor (IL-7R) alpha(+) cells inthe intestine indicates that defects of 117ra(-/-) and Lta(-/-) mice are due to functional inability of IL-7R alpha(+) cells in the induction of PP anlage. Blocking of IL-7R alpha function by a single injection of the antagonistic mAb in 15.5 d.p.c. embryos suppressed appearance of VCAM-1(+) spots and expression of LT alpha and LTP in the intestine, which eventually resulted in mice without PP but are otherwise normal. Intestinal IL-7R alpha(+) cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2(-/-) mice. These results implicate IL-7R alpha(+) CD3(-) cells as the direct inducer of the organizing center of PP.

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Documento generato il 26/01/20 alle ore 16:01:40