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Titolo:
Change in semen quality and sperm chromatin structure following occupational styrene exposure
Autore:
Kolstad, HA; Bonde, JP; Spano, M; Giwercman, A; Zschiesche, W; Kaae, D; Larsen, SB; Roeleveld, N;
Indirizzi:
Aarhus Univ Hosp, Dept Occupat Med, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C Occupat Med, DK-8000 Aarhus C, Denmark ENEA CR Casaccia, Dept Environm, Sect Toxicol & Biomed Sci, Rome, Italy ENEA CR Casaccia Rome Italy onm, Sect Toxicol & Biomed Sci, Rome, Italy Rigshosp, Dept Growth & Reprod, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 Reprod, DK-2100 Copenhagen, Denmark Univ Erlangen Nurnberg, Inst Occupat Med, Nurnberg, Germany Univ Erlangen Nurnberg Nurnberg Germany Occupat Med, Nurnberg, Germany Univ Nijmegen, Dept Epidemiol, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands ept Epidemiol, Nijmegen, Netherlands
Titolo Testata:
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
fascicolo: 3, volume: 72, anno: 1999,
pagine: 135 - 141
SICI:
0340-0131(199905)72:3<135:CISQAS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ETHYLENE-GLYCOL ETHERS; DRY-CLEANING WORKERS; PERCHLOROETHYLENE EXPOSURE; REPRODUCTION; FERTILITY; TOXICITY;
Keywords:
occupational exposure; spermatozoa; sperm count; epidemiology; genotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kolstad, HA Aarhusarkiv Hosp, Dept Occupat Med, Norrebrogade 44, DK-8000 Aarhus C, Denm Aarhus Univ Hosp Norrebrogade 44 Aarhus Denmark C hus C, Denm
Citazione:
H.A. Kolstad et al., "Change in semen quality and sperm chromatin structure following occupational styrene exposure", INT A OCCUP, 72(3), 1999, pp. 135-141

Abstract

Objectives: Organic solvents have been suspected to exert detrimental effects on human spermiogenesis. Styrene, which is both mutagenic and neurotoxic, was selected as a suitable organic solvent for further assessment csf a possible effect on semen quality and sperm DNA damage. Subjects and methods: Semen samples were collected from 23 reinforced plastics workers at the time of employment and after 6 months of styrene exposure and from 21 nonexposed farmers. Intra-individual changes in conventional semen parameters andsperm-DNA denaturation patterns were related to the internal dose of styrene exposure as measured by postshift urinary mandelic acid. Results: A statistically significant decline in sperm density was seen during styrene exposure from 63.5 to 46.0 million sperm/ml, whereas no decline was seen in thenonexposed subjects. The total sperm count was almost halved from an initial value of 175 million sperm/ejaculate. However, no relationship was apparent when the sperm parameters were related to internal levels of exposure. However, an exposure-response relationship was shown for DNA-denaturation patterns, but the numbers were small. Conclusion: A declining sperm count following styrene exposure is suggested. However; the findings of the internal and external comparisons are inconsistent, and this may be due to the high intraindividual variability of semen parameters and the limited study size but may also be attributable to a weak internal exposure gradient. Spermatogenesis may be vulnerable to styrene exposure. However, due to the small numbers these findings are only preliminary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:17:11