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Titolo:
The spectrum of microsatellite loci on chromosomes 7 and 8 in Taiwan aboriginal populations: a comparative population genetic study
Autore:
Wei, CC; Chiang, FT; Lin, KS; Lin, LI;
Indirizzi:
Natl Taiwan Univ, Coll Med, Inst & Sch Med Technol, Taipei, Taiwan Natl Taiwan Univ Taipei Taiwan , Inst & Sch Med Technol, Taipei, Taiwan Natl Taiwan Univ, Coll Med, Dept Lab Med, Taipei, Taiwan Natl Taiwan UnivTaipei Taiwan , Coll Med, Dept Lab Med, Taipei, Taiwan
Titolo Testata:
HUMAN GENETICS
fascicolo: 4, volume: 104, anno: 1999,
pagine: 333 - 340
SICI:
0340-6717(199904)104:4<333:TSOMLO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE DISEQUILIBRIUM; DNA POLYMORPHISMS; FREQUENCY; REPEAT; TECHNOLOGY; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, LI NatlTaiwann Univ, Coll Med, Inst & Sch Med Technol, 1 Chang Te St,Taipei, Natl Taiwan Univ 1 Chang Te St Taipei Taiwan hang Te St, Taipei,
Citazione:
C.C. Wei et al., "The spectrum of microsatellite loci on chromosomes 7 and 8 in Taiwan aboriginal populations: a comparative population genetic study", HUM GENET, 104(4), 1999, pp. 333-340

Abstract

Sixteen microsatellite loci on chromosomes 7 and 8 of Han-Taiwanese and six Taiwan aboriginal populations were systematically analyzed by a high-resolution multiple-fluorescence-based polymerase chain reaction technique. Analysis of allele frequency distribution indicated the generic divergence among these populations. Several alleles were unique to specific tribes. Only the D8S556 locus deviated from Hardy-Weinberg equilibrium in all tribes. Its F-IS level, as calculated with the Nei method, was also higher and more homozygous than expected. Therefore, with the exception of D8S556, these variable number of tandem repeats (VNTR) loci are suitable genetic markers forforensic and paternal testing. The F-ST level, as the proportion of the total variation among these tribes, ranged from 1.4% at the D7S484 locus to 6.8% at the D7S550 locus. The average F-ST was 3.9%, suggesting that there were substantial variations among these populations. The genetic identity analysis and the genetic distance analysis reached the same conclusions, viz., that the Ami and the Paiwan tribes were genetically close to each other, that the Atayal tribe was relatively unique compared with other tribes, andthat the Saisiat tribe was relatively close to the Han-Taiwanese. A dendrogram for these tribes was further constructed by the UPGMA method. These VNTR data not only facilitate forensic and paternity testing, but also provide anthropometric information for further elucidating the relationship of Taiwan populations to the Austronesian family.

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Documento generato il 09/07/20 alle ore 13:13:50