Catalogo Articoli (Spogli Riviste)

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Titolo:
Caspase inhibitors in prevention of apoptosis
Autore:
Rudel, T;
Indirizzi:
Max Planck Inst Infekt Biol, Mol Biol Abt, D-10117 Berlin, Germany Max Planck Inst Infekt Biol Berlin Germany D-10117 10117 Berlin, Germany
Titolo Testata:
HERZ
fascicolo: 3, volume: 24, anno: 1999,
pagine: 236 - 241
SICI:
0340-9937(199905)24:3<236:CIIPOA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; BACULOVIRUS P35 PROTEIN; CELL-DEATH; CYSTEINE PROTEASE; MUSCLE-FIBERS; KEY MEDIATORS; CYTOCHROME-C; FAS; ACTIVATION; RECEPTORS;
Keywords:
caspase; inhibitor; cardiomyocyte apoptosis; FLIP; IAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Rudel, T Maxermanyk Inst Infekt Biol, Mol Biol Abt, Monbijoustr 2, D-10117Berlin, G Max Planck Inst Infekt Biol Monbijoustr 2 Berlin Germany D-10117
Citazione:
T. Rudel, "Caspase inhibitors in prevention of apoptosis", HERZ, 24(3), 1999, pp. 236-241

Abstract

Apoptosis, a morphological distinct form of programmed cell death, is a crucial process during development, the maintenance of cell homeostasis and the regulation of the immune system. A variety of diseases have been found to correlate with physiological apoptosis including cancer, autoimmune disease, viral infection and degenerative disorders. Although very different signals initiate apoptosis, the phenotype of apoptosis is surprisingly similar even in different cell types suggesting that the final stages of apoptotic death are highly conserved. The execution of the death program is coordinated by a recently identified class of cysteine proteases termed caspases. The finding that caspases are mainly involved in regulation of this conserved part of the death program has boosted the search for caspase inhibitorswhich might offer a therapeutic approach to treat apoptotic disorders. Synthetic peptide inhibitors have been developed which exhibit Some selectivity for the different caspases. In the last years several natural inhibitors have been discovered which either prevent caspase activation or caspase activity. This review will present the recent advances and discuss the potential of caspase inhibitors as future therapeutics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:43:34