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Titolo:
Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
Autore:
Matteoni, CA; Younossi, ZM; Gramlich, T; Boparai, N; Liu, YC; McCullough, AJ;
Indirizzi:
Cleveland Clin Fdn, Dept Gastroenterol S40, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ol S40, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Liver Transplant Ctr & Biostat, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 iostat, Cleveland, OH 44195 USA Metrohlth Med Ctr, Dept Pathol, Cleveland, OH USA Metrohlth Med Ctr Cleveland OH USA d Ctr, Dept Pathol, Cleveland, OH USA Metrohlth Med Ctr, Div Gastroenterol, Cleveland, OH USA Metrohlth Med CtrCleveland OH USA Div Gastroenterol, Cleveland, OH USA
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 6, volume: 116, anno: 1999,
pagine: 1413 - 1419
SICI:
0016-5085(199906)116:6<1413:NFLDAS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; STEATOHEPATITIS; HEPATITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Younossi, ZM Cleveland44195 Fdn, Dept Gastroenterol S40, 9500 Euclid Ave, Cleveland, OH Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 OH
Citazione:
C.A. Matteoni et al., "Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity", GASTROENTY, 116(6), 1999, pp. 1413-1419

Abstract

Background & Aims: The spectrum of nonalcoholic fatty fiver disease rangesfrom fatty liver alone to nonalcoholic steatohepatitis. Most previous studies have short follow-up and have not carefully delineated different histological types when determining clinical outcomes. The aim of this study was to compare clinical characteristics and outcomes of patients with differenttypes of nonalcoholic fatty liver. Methods: All liver biopsy specimens from 1979 to 1987 with fat accumulation were assessed for inflammation, ballooning degeneration, Mallory hyaline, and fibrosis. Biopsy specimens were also assessed for histological iron and hepatitis C RNA. Outcomes were cirrhosis, mortality, and liver-related mortality. Results: Of 772 liver biopsy specimens, complete data were available in 132 patients. Fatty liver (type 1)did not differ from the other three types combined with respect to gender,race, age, or obesity. Cirrhosis was more common in the other types combined (22%) than fatty liver alone (4%; P < 0.001). Overall mortality, histological iron, and hepatitis C did not differ between groups. Most of the liver-related deaths were in type 4. Conclusions: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver. These poor outcomes are more frequent in patients in whom biopsiesshow ballooning degeneration and Mallory hyaline or fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:50:05