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Titolo:
Free radical activity following contraction-induced injury to the extensordigitorum longus muscles of rats
Autore:
McArdle, A; van der Meulen, JH; Catapano, M; Symons, MCR; Faulkner, JA; Jackson, MJ;
Indirizzi:
Univglandrpool, Dept Med, Muscle Res Ctr, Liverpool L69 3GA, Merseyside, En Univ Liverpool Liverpool Merseyside England L69 3GA 9 3GA, Merseyside, En Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 st Gerontol, Ann Arbor, MI 48109 USA De Montfort Univ, Dept Chem, Leicester LE1 9BH, Leics, England De MontfortUniv Leicester Leics England LE1 9BH LE1 9BH, Leics, England
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 9-10, volume: 26, anno: 1999,
pagine: 1085 - 1091
SICI:
0891-5849(199905)26:9-10<1085:FRAFCI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; LIPID-PEROXIDATION; ECCENTRIC EXERCISE; VITAMIN-E; GLUTATHIONE; DAMAGE; FIBERS; MICE; METABOLISM; PREVENTION;
Keywords:
lengthening contractions; glutathione; protein thiols; electron spin resonance; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, MJ Univglandrpool, Dept Med, Muscle Res Ctr, Liverpool L69 3GA, Merseyside, En Univ Liverpool Liverpool Merseyside England L69 3GA yside, En
Citazione:
A. McArdle et al., "Free radical activity following contraction-induced injury to the extensordigitorum longus muscles of rats", FREE RAD B, 26(9-10), 1999, pp. 1085-1091

Abstract

The purpose of the study was to investigate the role of free radicals in the injury induced by a protocol of repeated pliometric (lengthening) contractions to the extensor digitorum longus (EDL) muscle in situ in rats. Previous data have indicated that prior treatment with the antioxidant polyethylene glycol-superoxide dismutase reduced the damage that was apparent at 3 days following this type of exercise. Three hours and 3 days following the protocol, the magnitude of the semiquinone-derived free radical signal observed by electron spin resonance spectroscopy (ESR) was not different for exercised and non-exercised skeletal muscles. A reduction in the protein thiolcontent of muscle was evident at 3 h, and was still apparent at 3 days. Three hours after the protocol, the total muscle glutathione content and the percentage in the oxidized form were unchanged, but by 3 days the percentage of muscle glutathione present in the oxidized form was elevated. The susceptibility of muscle to lipid peroxidation in vitro was reduced 3 days after the pliometric contractions. These data indicate that oxidation of protein thiols and glutathione may be involved in the secondary damage following pliometric contractions, but provide no evidence that the species involved were derived from mitochondrial semiquinone radicals. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 05:37:41