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Titolo:
Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans
Autore:
Leighton, F; Cuevas, A; Guasch, V; Perez, DD; Strobel, P; San Martin, A; Urzua, U; Diez, MS; Foncea, R; Castillo, O; Mizon, C; Espinoza, MA; Urquiaga, I; Rozowski, J; Maiz, A; Germain, A;
Indirizzi:
Catholic Univ Chile, Fac Biol Sci, Santiago, Chile Catholic Univ Chile Santiago Chile Chile, Fac Biol Sci, Santiago, Chile Catholic Univ Chile, Fac Med, Santiago, Chile Catholic Univ Chile Santiago Chile Univ Chile, Fac Med, Santiago, Chile
Titolo Testata:
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
fascicolo: 2-3, volume: 25, anno: 1999,
pagine: 133 - 141
SICI:
0378-6501(1999)25:2-3<133:PPAAOD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; POTENTIAL TRAP; FRENCH PARADOX; VITAMINS; REACTIVITY; VEGETABLES; ALCOHOL; CANCER; FRUIT; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Leighton, F Catholic Univ Chile, Fac Biol Sci, Casilla 114-D, Santiago, Chile Catholic Univ Chile Casilla 114-D Santiago Chile iago, Chile
Citazione:
F. Leighton et al., "Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans", DRUG EXP CL, 25(2-3), 1999, pp. 133-141

Abstract

An intervention study was performed to evaluate the influence of a Mediterranean diet, a high fat diet, and their supplementation with red wine in moderate amounts, on biochemical, physiological, and clinical parameters related to atherosclerosis and other chronic diseases. For 3 months two groups of 21 male volunteers each, received either a Mediterranean diet or a high fat diet; during the second month, red wine was added isocalorically, 240 ml/day. Participants were kept under close medical and nutritional surveillance. Al days 0, 30 60 and 90, clinical, physiological and biochemical evaluations were made. Plasma vitamin C was significantly decreased in the high fat diet group compared to the Mediterranean diet group. After wine supplementation to the Mediterranean diet, a significant 13.5% increase in plasma vitamin C was observed. Furthermore, when wine was added vitamin E decreased significantly in plasma, 15% in the high fat diet and 26% in the Mediterranean diet. Total plasma antioxidant capacity (total antioxidant reactivity) increased 28% above basal levels in the Mediterranean diet group, but notin the high fat diet group. In both groups, wine induced a marked increasein total antioxidant reactivity above basal levels, 56% and 23%, respectively Oxidative DNA damage, detected as 8-hydroxydeoxyguanosine (8-OHdG) levels in blood leukocyte DNA, was markedly increased by the high fat diet; however, it was strongly reduced, to approximately 50% basal values, after wine supplementation, both in the high fat diet and Mediterranean diet groups. Endothelial function evaluated noninvasively as flow-mediated vascular reactivity of the brachial artery, was suppressed by the high fat diet and wasnormal after wine supplementation. These effects are attributed to oxidative stress associated with a high fat diet and to the elevated plasma antioxidant capacity associated with wine consumption and the Mediterranean diet. The results presented support the following conclusions: a high fat diet induces oxidative stress; a diet rich in fruits and vegetables enhances antioxidant defenses; wine supplementation to a high fat or a Mediterranean diet increases plasma antioxidant capacity, decreases oxidative DNA damage, and normalizes endothelial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:58:26