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Titolo:
Pharmacokinetic changes of a new carbapenem, DA-1131, after intravenous administration to spontaneously hypertensive rats and deoxycorticosterone acetate-salt-induced hypertensive rats
Autore:
Kim, SH; Kim, WB; Lee, MG;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 k Gu, Seoul 151742, South Korea Dong A Pharmaceut Co, Res Lab, Seoul, South Korea Dong A Pharmaceut Co Seoul South Korea Co, Res Lab, Seoul, South Korea
Titolo Testata:
DRUG METABOLISM AND DISPOSITION
fascicolo: 6, volume: 27, anno: 1999,
pagine: 710 - 716
SICI:
0090-9556(199906)27:6<710:PCOANC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOCA-SALT; TISSUE DISTRIBUTION; RENAL DIPEPTIDASE; DOSAGE REGIMENS; PHARMACODYNAMICS; METABOLISM; DOGS; ANTIBIOTICS; FUROSEMIDE; STABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, MG Seoul Natl Univ, Coll Pharm, Kwanak Gu, San 56-1, Seoul 151742, South Korea Seoul Natl Univ San 56-1 Seoul South Korea 151742 42, South Korea
Citazione:
S.H. Kim et al., "Pharmacokinetic changes of a new carbapenem, DA-1131, after intravenous administration to spontaneously hypertensive rats and deoxycorticosterone acetate-salt-induced hypertensive rats", DRUG META D, 27(6), 1999, pp. 710-716

Abstract

The pharmacokinetics of a new carbapenem, DA-1131, were compared after i.v. administration of the drug, 50 mg/kg, to spontaneously hypertensive rats (SHRs) at 16 weeks of age (an animal model for human primary hypertension) and at 6 weeks of age (corresponding to the early phase of the development of hypertension, at which time blood pressure remains within the normotensive range) and their respective age-matched control normotensive Kyoto-Wistar rats (KW rats), and deoxycorticosterone acetate-salt-induced hypertensiverats at 16 weeks of age (an animal model for human secondary hypertension)and their age-matched control Sprague-Dawley rats. The total area under the plasma concentration-time curve from time zero to time infinity (AUC) (4720 versus 7070 mu g.min/ml) was significantly smaller, and the nonrenal clearance (CLNR) (5.37 versus 3.57 ml/min/kg) was significantly faster in 16-week-old SHRs than those in their control KW rats. Similar results were alsoobtained from 6-week-old SHRs in AUC (3800 versus 4680 mu g min/ml) and CLNR (7.73 versus 3.31 ml/min/kg). However, the values were reversed in 16-week-old deoxycorticosterone acetate-salt rats in AUC (5310 versus 3870 mu g.min/ml) and CLNR (2.57 versus 4.90 ml/min/kg). The significantly faster CLNR of DA-1131 in both 6- and 16-week-old SHRs could be supported at least partly by the results of the in vitro metabolism with kidney homogenate and considerably greater total renal dehydropeptidase-1 activity. The data aboveindicated that the significantly faster CLNR of DA-1131 in 16-week-old SHRs than that in their age-matched control KW rats was due to any hereditary characteristics of SHRs and was not due to the hypertensive state itself.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:23:52