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Titolo:
Hormonal and behavioral homeostasis in boys at risk for substance abuse
Autore:
Dawes, MA; Dorn, LD; Moss, HB; Yao, JK; Kirisci, L; Ammerman, RT; Tarter, RE;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, CEDAR, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 , CEDAR, Pittsburgh, PA 15213 USA Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Nursing, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Allegheny15212 Hlth Sci, Dept Psychiat, Allegheny Gen Hosp, Pittsburgh, PAAllegheny Univ Hlth Sci Pittsburgh PA USA 15212 Gen Hosp, Pittsburgh, PA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1-2, volume: 55, anno: 1999,
pagine: 165 - 176
SICI:
0376-8716(19990601)55:1-2<165:HABHIB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT HYPERACTIVITY; FOLLOW-UP; YOUNG ADOLESCENTS; SALIVARY CORTISOL; PSYCHIATRIC-DISORDERS; LUTEINIZING-HORMONE; AGGRESSIVE-BEHAVIOR; SELF-REGULATION; TESTOSTERONE; CHILDREN;
Keywords:
substance abuse liability; hormonal and behavioral homeostasis; personality; family and peer dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Dawes, MA UnivPAittsburgh, Sch Med, Dept Psychiat, CEDAR, 3811 OHara St, Pittsburgh, Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 ittsburgh,
Citazione:
M.A. Dawes et al., "Hormonal and behavioral homeostasis in boys at risk for substance abuse", DRUG AL DEP, 55(1-2), 1999, pp. 165-176

Abstract

This study modeled the influences of cortisol reactivity, androgens, age-corrected pubertal status, parental personality, family and peer dysfunctionon behavioral self-regulation (BSR), in boys at high (HAR) and low averagerisk (LAR) for substance abuse. Differences between risk groups in cortisol and androgen concentrations, and cortisol reactivity were also examined. Subjects were 10- through 12-year-old sons of substance abusing fathers (HAIR; n = 150) and normal controls (LAR; n = 147). A multidimensional construct of BSR was developed which utilized multiple measures and multiple informants. Boys reported on family dysfunction and deviant behavior among theirpeers. Parents reported on their propensity to physically abuse their sons, and their own number of DSM-III-R Antisocial Personality Disorder symptoms. Endocrine measures included plasma testosterone, dihydrotestosterone, and salivary cortisol. HAR boys, compared to LAR boys, had lower mean concentrations for testosterone, dihydrotestosterone, salivary cortisol prior to evoked related potential testing, and lower cortisol reactivity. The number of maternal Antisocial Personality Disorder symptoms, parental potential for physical abuse, degree of family dysfunction, and peer delinquency were significantly associated with BSR. Parental aggression antisocial personality symptoms and parental physical abuse potential are likely to influence sons' behavioral dysregulation and homeostatic stress reactivity. These key components of liability are posited to increase the likelihood of developingsuprathreshold Psychoactive Substance Use Disorder (PSUD). (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 16/01/21 alle ore 08:17:04