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Titolo:
Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygons and DR4/4 homozygous offspring of parents with Type I diabetes: The German BABYDIAB study
Autore:
Schenker, M; Hummel, M; Ferber, K; Walter, M; Keller, E; Albert, ED; Janka, HU; Kastendiek, C; Sorger, M; Louwen, F; Ziegler, AG;
Indirizzi:
Krankenhaus Munster Schwabing, Diabet Res Inst, Dept Med 3, D-80804 Munich, Krankenhaus Munster Schwabing Munich Germany D-80804 3, D-80804 Munich, Univ Munich, Immunogenet Lab, Munich, Germany Univ Munich Munich Germany niv Munich, Immunogenet Lab, Munich, Germany Cent Hosp Bremen N, Bremen, Germany Cent Hosp Bremen N Bremen GermanyCent Hosp Bremen N, Bremen, Germany Univ Bonn, Med Poliklin, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 v Bonn, Med Poliklin, D-5300 Bonn, Germany Univ Munster, Dept Obstet, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 Dept Obstet, D-4400 Munster, Germany Diabet Res Inst, Munich, Germany Diabet Res Inst Munich GermanyDiabet Res Inst, Munich, Germany
Titolo Testata:
DIABETOLOGIA
fascicolo: 6, volume: 42, anno: 1999,
pagine: 671 - 677
SICI:
0012-186X(199906)42:6<671:EEAHPO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CELL ANTIBODIES; INSULIN; RELATIVES; AUTOIMMUNITY; HLA; MELLITUS; RISK; IDDM; MICE;
Keywords:
HLA genotype; Type I diabetes; islet autoimmunity; autoantibody appearance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, AG Krankenhaus80804ter Schwabing, Diabet Res Inst, Dept Med 3, Kolner Pl 1, D- Krankenhaus Munster Schwabing Kolner Pl 1 Munich Germany D-80804
Citazione:
M. Schenker et al., "Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygons and DR4/4 homozygous offspring of parents with Type I diabetes: The German BABYDIAB study", DIABETOLOG, 42(6), 1999, pp. 671-677

Abstract

Aims/hypothesis. Islet autoantibodies precede the clinical onset of Type I(insulin-dependent) diabetes mellitus. The cumulative development of such autoantibodies in infants followed from birth and in particular infants with high-risk HLA genotypes is poorly defined, but such information is essential to design trials to prevent islet autoimmunity. Methods. HLA genotypes were determined in offspring of parents with Type Idiabetes who were followed from birth for at least 2 years (median followup: 3.1 years) and who were characterised for the expression of insulin, GAD65, IA-2 and islet cell autoantibodies at birth, 9 months, 2 and 5 years ofage. Results. The HLA genotypes DRB1*03/04(DQB1*57non-Asp) and DRB1*04/04(DQB1*57non-Asp) were present in 7.1 % and 5.0 % of offspring of parents with Type I diabetes. The frequency of both genotypes was increased in offspring who developed islet autoantibodies within the first 2 years of life (27.3 % vs 5.5 %, odds ratio 6.3 [p = 0.002] and 22.7 % vs 4.2 %, odds ratio 6.6 [p = 0.003]) and half of all offspring who developed antibodies had these genotypes. Other genotypes were not associated with an increase in risk. By life-table analysis, the cumulative risk of developing islet autoantibodies bythe age of 2 years was 20 % (95 % CI 9.4,30.6) for offspring carrying either the DRB1*03/04(DQB1 *57non-Asp) or the DRB1*04/04(DQB1*57non-Asp) genotype compared with 2.7 % (95 % CI 1.2,4.2) for offspring without these genotypes (p < 0.0001). Conclusion/interpretation. These data show that early appearance of islet autoantibodies is remarkably frequent for DR3/4 heterozygous and DR4/4 homozygous offspring and indicate that primary prevention could be considered once available in an offspring cohort selected for these genotypes.

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Documento generato il 25/11/20 alle ore 10:18:45