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Titolo:
Evaluation of serum markers of neuronal damage following severe hypoglycaemia in adults with insulin-treated diabetes mellitus
Autore:
Strachan, MWJ; Abraha, HD; Sherwood, RA; Lammie, GA; Deary, IJ; Ewing, FME; Perros, P; Frier, BM;
Indirizzi:
Univlothian,gh, Royal Infirm Edinburgh, Dept Diabet, Edinburgh EH3 9YW, Mid Univ Edinburgh Edinburgh Midlothian Scotland EH3 9YW inburgh EH3 9YW, Mid Univ London Kings Coll, Sch Med & Dent, Dept Clin Biochem, London, EnglandUniv London Kings Coll London England ept Clin Biochem, London, England Western Gen Hosp, Dept Neuropathol, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland FreemaneRd Hosp, Dept Endocrinol & Diabet, Newcastle Upon Tyne NE7 7DN, Tyn Freeman Rd Hosp Newcastle Upon Tyne Tyne & Wear England NE7 7DN 7DN, Tyn
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 1, volume: 15, anno: 1999,
pagine: 5 - 12
SICI:
1520-7552(199901/02)15:1<5:EOSMON>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; S-100 PROTEIN; SUBARACHNOID HEMORRHAGE; ENOLASE CONCENTRATIONS; SEVERE HYPOGLYCEMIA; NEUROLOGICAL DISORDERS; CARDIAC-ARREST; BRAIN-DAMAGE;
Keywords:
neurone-specific enolase; protein S-100; hypoglycaemia; insulin-treated diabetes; neuroglycopenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Strachan, MWJ UnivhEdinburgh, Royal Infirm Edinburgh, Dept Diabet, Lauriston Pl, Edinburg Univ Edinburgh Lauriston Pl Edinburgh Midlothian Scotland EH3 9YW
Citazione:
M.W.J. Strachan et al., "Evaluation of serum markers of neuronal damage following severe hypoglycaemia in adults with insulin-treated diabetes mellitus", DIABET M R, 15(1), 1999, pp. 5-12

Abstract

Background Neurone-specific enolase (NSE) and protein S-100 (S-100) may beused as markers of acute neuronal damage in humans with neurological disorders. Method To evaluate their use following a single episode of severe hypoglycaemia (defined as an episode requiring external assistance to aid recovery), serum concentrations of NSE and S-100 were measured following hypoglycaemia which had not caused persistent neurological impairment in 16 patients with insulin-treated diabetes (the 'hypo' subjects), and in three diabetic patients who died following severe hypoglycaemia. The serum proteins were also measured in 10 subjects with insulin-treated diabetes who had not experienced an episode of severe hypoglycaemia within the preceding year (the 'control' subjects). Results No differences in serum concentrations of NSE and S-100 were observed between the 'control' and the 'hypo' subjects at either 36 hours or seven days after the episode of severe hypoglycaemia (p>0.05). However, in twoof the three subjects who died following hypoglycaemia, serum concentrations of the markers were markedly elevated. Conclusions. Any neuronal injury occurring during severe hypoglycaemia that is not associated with persistent neurological deficit is insufficient toprovoke elevation of these serum markers. However, the measurement of serum concentrations of NSE and S-100 may have a prognostic role in evaluating clinical outcome following severe hypoglycaemia which is associated with neurological damage. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 12:59:29