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Titolo:
Electromechanical characterization of myocardial hibernation in a pig model
Autore:
Fuchs, S; Kornowski, R; Shiran, A; Pierre, A; Ellahham, S; Leon, MB;
Indirizzi:
Washington Cardiol Ctr, Washington, DC 20010 USA Washington Cardiol Ctr Washington DC USA 20010 , Washington, DC 20010 USA
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 3, volume: 10, anno: 1999,
pagine: 195 - 198
SICI:
0954-6928(199905)10:3<195:ECOMHI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY STENOSIS; CONSCIOUS PIGS;
Keywords:
endocardial mapping; hibernation; myocardial viability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kornowski, R Washington Cardiol Ctr, 110 Irving St NW,4B-1, Washington, DC20010 USA Washington Cardiol Ctr 110 Irving St NW,4B-1 Washington DC USA 20010
Citazione:
S. Fuchs et al., "Electromechanical characterization of myocardial hibernation in a pig model", CORON ART D, 10(3), 1999, pp. 195-198

Abstract

Background This study attempted to assess in-vivo electromechanical changes following gradual coronary artery occlusion in a pig ameroid constrictor model using a novel three-dimensional left ventricular mapping system. Methods and results We measured unipolar and bipolar voltage potentials and local endocardial shortening in the ischemic lateral and non-ischemic anterior zones in animals at rest (n=9) 5 weeks after the implantation of ameroid constrictors around the left circumflex artery. Echocardiography was used to assess regional contractility (percentage myocardial thickening), andan echo-contrast perfusion study was performed using acoustic densitometrymethods. The ischemic lateral zone showed reduced myocardial perfusion at rest (peak intensity; 3.4 +/- 1.7 versus 20.7 +/- 14.8, P= 0.005), impairedmechanical function (percentage wall thickening 22 +/- 19% versus 40 +/- 11%, P = 0.03; local endocardial shortening 2.9 +/- 5.5% versus 11.7 +/- 2.1%, P= 0.002), and preserved electrical activity (unipolar voltage 12.4 +/- 4.7 versus 14.4 +/- 1.9 mV, P = 0.25; bipolar voltage 4.1 +/- 1.1 versus 3.8 +/- 1.5 mV, P= 0.62), compared with the anterior region. Conclusions Gradual coronary artery occlusion resulting in regional reduced perfusion and function at rest (i.e. hibernating myocardium) is characterized by preserved electrical activity., An electromechanical left ventricular mapping procedure such as the one described here may be of diagnostic value for identifying the hibernating myocardium. Coronary Artery Dis 10:195-198 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:14:48