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Titolo:
Effects of two different ACE inhibitors, captopril and delapril, in the early phases of acute anterior myocardial infarction
Autore:
Di Pasquale, P; Cannizzaro, S; Scalzo, S; Bucca, V; Maringhini, G; Lo Verso, P; Giubilato, A; Paterna, S;
Indirizzi:
GF Ingrassia Hosp, Div Cardiol Paolo Borsellino, Palermo, Italy GF Ingrassia Hosp Palermo Italy ardiol Paolo Borsellino, Palermo, Italy Univ Palermo, Dept Internal Med, Palermo, Italy Univ Palermo Palermo Italy v Palermo, Dept Internal Med, Palermo, Italy
Titolo Testata:
CLINICAL DRUG INVESTIGATION
fascicolo: 5, volume: 17, anno: 1999,
pagine: 347 - 355
SICI:
1173-2563(199905)17:5<347:EOTDAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; LEFT-VENTRICULAR DYSFUNCTION; FREE-RADICALS; THERAPY; REPERFUSION; MORTALITY; SURVIVAL; TRIAL; THROMBOLYSIS; COMBINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Di Pasquale, P Via Val Platani 3, I-90144 Palermo, Italy Via Val Platani 3 Palermo Italy I-90144 44 Palermo, Italy
Citazione:
P. Di Pasquale et al., "Effects of two different ACE inhibitors, captopril and delapril, in the early phases of acute anterior myocardial infarction", CLIN DRUG I, 17(5), 1999, pp. 347-355

Abstract

Objective: This study was aimed at investigating the effects of captopril or delapril before and just after thrombolysis in acute anterior myocardialinfarction (AMI). Patients and Methods: Study participants consisted of 89 patients, hospitalised within 4 hours of the onset of symptoms. Patients were randomly divided into two groups: the first group (45 patients, pretreatment group) received captopril 6.25mg or delapril 7.5mg orally about 15 minutes before intravenous administration of recombinant tissue plasminogen activator (rt-PA) 100mg; the second group (44 patients, late-treatment group) received captopril or delapril about 4 to 6 hours after thrombolytic treatment. Captopril/delapril doses were later increased in both groups according to changes in systolic blood pressure of >100mm Hg. Ventricular arrhythmias (VA) due to reperfusion were evaluated during the first 2 hours. Results: VA occurred in 13 patients receiving pretreatment vs 30 patients receiving late treatment (p = NS). Creatine kinase (CK) peak normalisation time was achieved after 56.6 +/- 13 hours (captopril group: 22 patients) and 58 +/- 16 hours (delapril group: 23 patients) vs 68 +/- 17 hours (captopril: 22 patients) and 70 +/- 18 hours (delapril: 22 patients) in the late-treatment group (p < 0.05). CK peak did not show significant differences. Late arrhythmias, Lown's class >2, occurred in five patients receiving pretreatment vs nine patients receiving late treatment (p = NS), at predischarge Holter rest. 86 patients underwent haemodynamic testing about 7 to 10 days after AMI. Ejection fraction did not show any significant difference betweenall groups, whereas end-systolic volume was statistically reduced in patients receiving pretreatment. Follow-up was carried out on 86 patients. Two patients in the late-treatment group experienced heart failure and one died 6 months after discharge. Conclusion: Our data suggested that captopril and delapril produced similar pharmacodynamic effects in patients With anterior AMI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:58:44