Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging
Autore:
Hendel, RC; Berman, DS; Cullom, SJ; Follansbee, W; Heller, GV; Kiat, H; Groch, MW; Mahmarian, JJ;
Indirizzi:
Northwestern Univ, Sch Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 iv, Sch Med, Chicago, IL 60611 USA Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Emory Univ, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322Emory Univ, Atlanta, GA 30322 USA Univ Pittsburgh, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 tsburgh, Pittsburgh, PA 15213 USA Hartford Hosp, Hartford, CT 06115 USA Hartford Hosp Hartford CT USA 06115Hartford Hosp, Hartford, CT 06115 USA Sydney Cardiol Grp, Westmead, NSW, Australia Sydney Cardiol Grp Westmead NSW Australia Grp, Westmead, NSW, Australia Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA
Titolo Testata:
CIRCULATION
fascicolo: 21, volume: 99, anno: 1999,
pagine: 2742 - 2749
SICI:
0009-7322(19990601)99:21<2742:MCTTET>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; SIMULTANEOUS TRANSMISSION; NONUNIFORM ATTENUATION; DIAGNOSTIC-ACCURACY; CARDIAC SPECT; LINE SOURCE; TL-201; ARTIFACTS; QUANTIFICATION;
Keywords:
imaging; perfusion; nuclear medicine; diagnosis; radioisotopes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hendel, RC 250 E Super St,Suite 456, Chicago, IL 60611 USA 250 E Super St,Suite 456 Chicago IL USA 60611 go, IL 60611 USA
Citazione:
R.C. Hendel et al., "Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging", CIRCULATION, 99(21), 1999, pp. 2742-2749

Abstract

Background-Soft tissue attenuation is a prominent cause of single-photon emission computed tomography (SPECT) imaging artifacts, which may result in reduced diagnostic accuracy of myocardial perfusion imaging. A method incorporating simultaneously acquired transmission data permits nonuniform attenuation correction and when incorporating scatter correction and resolution compensation may substantially reduce interpretive errors,Methods and Results-A prospective multicenter trial was performed recruiting patients with angiographically documented coronary disease (n = 96) and group of subjects with a low likelihood of disease (n = 88). The uncorrected and attenuation/scatter corrected images were read independently, withoutknowledge of the patient's clinical data. The detection of greater than orequal to 50% stenosis was similar using uncorrected perfusion data or withattenuation/scatter correction and resolution compensation (visual or visual plus quantitative analysis), 76% versus 75% versus 78%, respectively (P=NS). The normalcy rate, however, was significantly improved with this new methodology, using either the corrected images (86% vs 96%; P=0.011) or withthe corrected data and quantitative analysis (86% vs 97%; P=0.007). The receiver operator characteristic curves were also found to be marginally but not significantly higher with attenuation/scatter correction than with tradition SPECT imaging. However, the ability to detect multivessel disease wasreduced with attenuation/scatter correction, Regional differences were also noted, with reduced sensitivity but improved specificity for right coronary lesions using attenuation/scatter correction methodology. Conclusions-This multicenter trial demonstrates the initial clinical results of a new SPECT perfusion imaging modality incorporating attenuation and scatter correction in conjunction with Tc-99m sestamibi perfusion imaging, Significant improvements in the normalcy rate were noted without a decline in overall sensitivity but with a reduction in detection of extensive coronary disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:02:59