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Titolo:
Morphine treatment during juvenile isolation increases social activity andopioid peptides release in the adult rat
Autore:
Van den Berg, CL; Kitchen, I; Gerrits, MAFM; Spruijt, BM; Van Ree, JM;
Indirizzi:
Univ3584echt, Dept Med Pharmacol, Rudolf Magnus Inst Neurosci, Fac Med, NL- Univ Utrecht Utrecht Netherlands NL-3584 CG Inst Neurosci, Fac Med, NL- Univglandey, Sch Biol Sci, Pharmacol Res Grp, Guildford GU2 5XH, Surrey, En Univ Surrey Guildford Surrey England GU2 5XH uildford GU2 5XH, Surrey, En
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 830, anno: 1999,
pagine: 16 - 23
SICI:
0006-8993(19990529)830:1<16:MTDJII>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVIVO AUTORADIOGRAPHIC ANALYSIS; OPIATE RECEPTOR; REWARD PATHWAYS; BRAIN; BINDING; PLAY; BEHAVIOR; LOCALIZATION; STIMULATION; SYSTEMS;
Keywords:
juvenile isolation; social play behavior; play period; social interaction test; autoradiography; opioid receptor mapping; [H-3]-diprenorphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Van Ree, JM UnivetherlandsRudolf Magnus Inst Neurosci, POB 80040, NL-3508 TA Utrecht, N Univ Utrecht POB 80040 Utrecht Netherlands NL-3508 TA echt, N
Citazione:
C.L. Van den Berg et al., "Morphine treatment during juvenile isolation increases social activity andopioid peptides release in the adult rat", BRAIN RES, 830(1), 1999, pp. 16-23

Abstract

The consequences of juvenile isolation and morphine treatment on general activity, social activity and endogenous opioid release during a social interaction test were investigated in the adult rat. Rats were either isolated or socially housed during weeks 4 and 5 of age and treated daily during this isolation period subcutaneously with either saline or morphine. Directly after a social interaction test at 10 weeks of age, rats were injected with[H-3]-diprenorphine and subsequently prepared for in vivo autoradiography. The autoradiographic technique was used to visualise neuroanatomical changes in opioid receptor occupancy, probably reflecting changes in opioid peptide release, as a result of social activity. Juvenile isolation increased general activity during the social interaction test, an effect which was accompanied by a reduction of opioid receptor occupancy in many brain areas, suggesting an increased opioid peptide release as a consequence of socially-induced general activity. Morphine treatment in isolated rats caused an increase in adult social activity and enhanced opioid peptide release in some cortical regions and the ventral tegmental area as compared to saline treated rats. Both social activity and opioid receptor occupancy were unaffectedby morphine treatment in non-isolated rats. The present study underscores the role of opioid systems in adult social behaviors as a consequence of juvenile isolation. The results suggest a relationship between social activity and opioid peptide release during social contact. Increased social activity seems to be accompanied by elevated opioid peptide release in distinct brain areas after morphine treatment during juvenile isolation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:57:07