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Titolo:
Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis
Autore:
Matthes-Martin, S; Lamche, M; Ladenstein, R; Emminger, W; Felsberger, C; Topf, R; Gadner, H; Peters, C;
Indirizzi:
St Anna Childrens Hosp, A-1090 Vienna, Austria St Anna Childrens Hosp Vienna Austria A-1090 osp, A-1090 Vienna, Austria
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 10, volume: 23, anno: 1999,
pagine: 1049 - 1053
SICI:
0268-3369(199905)23:10<1049:OTAQOL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL-BODY IRRADIATION; VERSUS-HOST DISEASE; COMPLETE REMISSION; ACUTE-LEUKEMIA; OF-LIFE; CHILDREN; SURVIVORS; DONORS;
Keywords:
allogeneic bone marrow transplantation; children; late effects; toxicity; quality of life;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Matthes-Martin, S St Anna Childrens Hosp, Kinderspitalgasse 6, A-1090 Vienna, Austria St Anna Childrens Hosp Kinderspitalgasse 6 Vienna Austria A-1090
Citazione:
S. Matthes-Martin et al., "Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis", BONE MAR TR, 23(10), 1999, pp. 1049-1053

Abstract

One hundred and fifty five pediatric patients underwent allogeneic bone marrow transplantation between 1980 and 1996 in the St Anna Children's Hospital in Vienna with an overall survival of 52.3% (81 patients). Seventy-threepatients with a minimum observation time of 1 year (1-13 years, median: 4.6) were analyzed retrospectively for chronic GVHD, organ toxicity (WHO score), growth and pubertal development. Chronic GVHD was diagnosed in 20 patients (27.3%), being extensive in 17 cases. Maximum organ toxicity was WHO III in two patients (3%) and WHO II in 11 patients (15%) 1 year after BMT andWHO III in one patient (2%) and WHO II in five patients (11%) 3 years after BMT. Impaired growth and pubertal development were detected in more than 30% 3 years after BMT, As all patients presented with a Karnofsky or Lanskyscore of more than 80%, they were asked to complete a questionnaire comprising 12 questions concerning physical state of health and psychosocial state of health. Restricted contacts were classified as imposing a severe handicap by six patients (8%), restriction in mobility and 'normal life activities' by three patients (4%) and two patients classified themselves as severely physically handicapped. Most patients (75%) reported no physical or psychical impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:18:59