Catalogo Articoli (Spogli Riviste)


A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover
Garnero, P; Darte, C; Delmas, PD;
Hop Edouard Herriot, INSERM, U403, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 INSERM, U403, F-69437 Lyon 03, France Beckman Coulter, Liege, Belgium Beckman Coulter Liege BelgiumBeckman Coulter, Liege, Belgium
Titolo Testata:
fascicolo: 6, volume: 24, anno: 1999,
pagine: 603 - 609
alendronate; bisphosphonate; bone marker; osteoporosis; bone alkaline phosphatase; dual-energy x-ray absorptiometry (DXA);
Tipo documento:
Settore Disciplinare:
Clinical Medicine
Life Sciences
Indirizzi per estratti:
Indirizzo: Garnero, P Hop Edouard Herriot, INSERM, U403, Pavillon F, F-69437 Lyon 03,France Hop Edouard Herriot Pavillon F Lyon France 03 Lyon 03, France
P. Garnero et al., "A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover", BONE, 24(6), 1999, pp. 603-609


Markers of bone turnover have been suggested to be useful in monitoring the long-term efficacy of antiresorptive therapy on hone mineral density (BMD). In this study, we developed a new model based on the combination of a marker level and its percent change at 6 months of therapy to predict longterm response in BMD, Serum bone alkaline phosphatase (BAP) was measured in 307 late postmenopausal women (mean age 64 years) with osteoporosis enrolled in a 2 year placebo-controlled trial of the bisphosphonate alendronate (10 mg/day), Under treatment, the maximal decrease was observed at 6 months (-44%) with no further change during the 2 year period. Both BAP levels at 6 months and percent BAP change at 6 months correlated with the percent changeof spine BMD at 2 years (r = -0.51 and -0.53, respectively, p < 0.001 for both). Logistic regression analysis showed that BAP levels and percent BAP change at 6 months are independent predictors of long-term positive BMD response, defined as greater than or equal to 3% increase in spine BMD at 2 years. The most relevant clinical option that could lead to therapeutic adjustment is likely to be an accurate identification of nonresponders, and thuspredictive models need to be highly specific. For a 90% specificity, the combination of both the percent change and BAP levels at 6 months resulted in a significantly (p < 0.05) higher sensitivity (72%) than using percent BAP change (61%) or BAP level at 6 months (59%) alone. This combination modelwas also more effective than using the least-significant change (a decrease of BAP at 6 months of >44%) based on the within-patient variability in the placebo group. In the combination model, positive BMD responders vs. nonresponders could easily be distinguished by a line on a two-scale graph (BAPlevel at 6 month vs. percent BAP change at 6 months). In conclusion, the combination of BAP level and of its percent change after 6 months of treatment in a logistic model improved the prediction of the long-term BMD response to alendronate treatment compared with percent BAP change alone, This newmodel may be useful for quick and accurate identification of noncompliant patients (i.e., nonresponders) vs. responders to alendronate treatment, although prospective studies are required to determine accurately the rate of false positives and false negatives. Because this model is independent of the study design, it should be broadly applicable. (Bone 24:603-609; 1999) (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:39:29