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Titolo:
Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP),a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat
Autore:
Cuzzocrea, S; Costantino, G; Mazzon, E; Zingarelli, B; De Sarro, A; Caputi, AP;
Indirizzi:
Univ Messina, Sch Med, Inst Pharmacol, I-98123 Messina, Italy Univ Messina Messina Italy I-98123 nst Pharmacol, I-98123 Messina, Italy Univ Messina, Sch Med, Dept Biomorphol, I-98123 Messina, Italy Univ Messina Messina Italy I-98123 pt Biomorphol, I-98123 Messina, Italy Childrens Hosp Med Ctr, Div Crit Care Med, Cincinnati, OH USA Childrens Hosp Med Ctr Cincinnati OH USA it Care Med, Cincinnati, OH USA
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 1, volume: 58, anno: 1999,
pagine: 171 - 176
SICI:
0006-2952(19990701)58:1<171:PEOM(A>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CELLULAR-ENERGY DEPLETION; ADP-RIBOSE SYNTHETASE; PEROXYNITRITE SCAVENGER; LOCAL INFLAMMATION; INDUCED PLEURISY; ENDOTOXIC-SHOCK; INDUCED MODELS; DNA-DAMAGE; IN-VITRO;
Keywords:
nitric oxide; peroxynitrite; carrageenan; superoxide dismutase; inflammation; paw oedema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Cuzzocrea, S Univna,ssina, Sch Med, Inst Pharmacol, Piazza 20 Settembre 4,I-98123 Messi Univ Messina Piazza 20 Settembre 4 Messina Italy I-98123 ssi
Citazione:
S. Cuzzocrea et al., "Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP),a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat", BIOCH PHARM, 58(1), 1999, pp. 171-176

Abstract

In the present study we investigated thr therapeutic efficacy of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic which possesses peroxynitrite scavenging effects, in rats subjected to carrageenan-induced paw oedema. Local administration of MnTBAP (5, 25, and 50 mu g/paw) significantly and dose dependently reduced carrageenan-induced pawoedema at all time points. MnTBAP also caused a significant dose-dependentreduction in paw myeloperoxidase activity and lipid peroxidation, as well as preventing histological injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in paw from carrageenan-treated rats. No positive nitrotyrosine staining was found in the paws of the carrageenan-treated rats that received MnTBAP. Our study demonstrates that MnTBAP exerts protective effects in carrageenan-induced paw oedema. Part of these anti-inflammatory effects may be related to: 1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound; and 2) scavenging of peroxynitrite. BIOCHEM PHARMACOL 58;1:171-176, 1999. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:55:22