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Titolo:
Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats
Autore:
Serra, M; Dazzi, L; Caddeo, M; Floris, C; Biggio, G;
Indirizzi:
Univ Cagliari, Dept Expt Biol, Chair Pharmacol, I-09123 Cagliari, Italy Univ Cagliari Cagliari Italy I-09123 Pharmacol, I-09123 Cagliari, Italy
Titolo Testata:
BIOCHEMICAL PHARMACOLOGY
fascicolo: 1, volume: 58, anno: 1999,
pagine: 145 - 149
SICI:
0006-2952(19990701)58:1<145:RBFOTD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEIZURES; CHANNELS; MODELS; GLUTAMATE; MEMORY; DEATH; BRAIN;
Keywords:
kindling; acetylcholine release; pentylenetetrazol; flunarizine; nifedipine; (-)-sulpiride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Serra, M Univagliari,i, Dept Expt Biol, Chair Pharmacol, Via Palabanda 12,I-09123 C Univ Cagliari Via Palabanda 12 Cagliari Italy I-09123 I-09123 C
Citazione:
M. Serra et al., "Reversal by flunarizine of the decrease in hippocampal acetylcholine release in pentylenetetrazole-kindled rats", BIOCH PHARM, 58(1), 1999, pp. 145-149

Abstract

The aim of our study was to evaluate the effect of the non-selective calcium antagonist flunarizine on hippocampal acetylcholine (ACh) release with the microdialysis technique in freely moving rats after long-term concomitant administration of pentylenetetrazole (PTZ) in comparison with rats treated long-term with PTZ (kindled animals). The basal extracellular concentration of ACh in the hippocampus of rats treated with PTZ alone was significantly reduced relative to that of vehicle-created rats (2.04 +/- 0.2 vs 3.94 +/- 0.3 pmol per 20-min sample; P < 0.01) Administration of flunarizine (7.5mg/kg i.p.) before each PTZ injection prevented this decrease in basal AChoutput (3.75 +/- 0.4 pmol per 20 min sample). On the contrary, the expression of PTZ-induced kindling was not prevented by administration of flunarizine. The specific antagonistic effect of flunarizine on the kindling-induced decrease in hippocampal ACh release is shared by the selective antagonistof the L-type calcium channel, nifedipine, but not by die dopamine D-2 antagonist, (-)-sulpiride, suggesting that the decrease in Ca2+ overload by a blockade of the L-type calcium channel may be responsible for the protective action on cholinergic neurons exerted by flunarizine. These data also suggest a potential therapeutic role for flunarizine in counteracting impairment of hippocampal cholinergic activity. BIOCHEM PHARMACOL 58;1:145-149, 1999. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 02:32:49