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Titolo:
Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging
Autore:
Goldstein, JM; Goodman, JM; Seidman, LJ; Kennedy, DN; Makris, N; Lee, H; Tourville, J; Caviness, VS; Faraone, SV; Tsuang, MT;
Indirizzi:
Harvardolniv, Sch Med, Massachusetts Mental Hlth Ctr, Inst Psychiat Epidemi Harvard Univ Boston MA USA 02115 s Mental Hlth Ctr, Inst Psychiat Epidemi Harvard,Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston Harvard Univ Boston MA USA 02115 s Mental Hlth Ctr, Dept Psychiat, Boston Harvardnal,v, Sch Med, Massachusetts Gen Hosp, Dept Neurol,Ctr Morphometr A Harvard Univ Boston MA USA 02115 s Gen Hosp, Dept Neurol,Ctr Morphometr A Harvardetriv, Sch Med, Massachusetts Gen Hosp, Dept Radiol Serv,Ctr Morphom Harvard Univ Boston MA USA 02115 s Gen Hosp, Dept Radiol Serv,Ctr Morphom Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Brockton W Roxbury Vet Affairs Med Ctr, Brockton, MA USA Brockton W Roxbury Vet Affairs Med Ctr Brockton MA USA Brockton, MA USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 6, volume: 56, anno: 1999,
pagine: 537 - 547
SICI:
0003-990X(199906)56:6<537:CAISIB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; GRAY-MATTER VOLUME; SUPERIOR TEMPORAL GYRUS; ANTERIOR CINGULATE CORTEX; PREFRONTAL CORTEX; SEX-DIFFERENCES; BRAIN MORPHOLOGY; FUNCTIONAL-ANATOMY; PLANUM TEMPORALE; CEREBRAL-CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Goldstein, JM Harvardolniv, Sch Med, Massachusetts Mental Hlth Ctr, Inst Psychiat Epidemi Harvard Univ 74 Fenwood Rd Boston MA USA 02115 chiat Epidemi
Citazione:
J.M. Goldstein et al., "Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging", ARCH G PSYC, 56(6), 1999, pp. 537-547

Abstract

Background: Relatively few magnetic resonance imaging studies of schizophrenia have investigated the entire cerebral cortex. Most focus on only a fewareas within a lobe or an entire lobe. To assess expected regional alterations in cortical volumes, we used a new method to segment the entire neocortex into 48 topographically defined brain regions. We hypothesized, based on previous empirical and theoretical work, that dorsolateral prefrontal andparalimbic cortices would be significantly volumetrically reduced in patients with schizophrenia compared with normal controls. Methods: Twenty-nine patients with DSM-III-R schizophrenia were systematically sampled from 3 public outpatient service networks in the Boston, Mass,area. Healthy subjects, recruited from catchment areas from which the patients were drawn, were screened for psychopathologic disorders and proportionately matched to patients by age, sex, ethnicity, parental socioeconomic status, reading ability, and handedness. Analyses of covariance of the volumes of brain regions, adjusted for age- and sex-corrected head size, were used to compare patients and controls. Results: The greatest volumetric reductions and largest effect sizes were in the middle frontal gyrus and paralimbic brain regions, such as the frontomedial and frontoorbital cortices, anterior cingulate and paracingulate gyri, and the insula. In addition, the supramarginal gyrus, which is densely connected to prefrontal and cingulate cortices, was also significantly reduced in patients. Patients also had subtle volumetric increases in other cortical areas with strong reciprocal connections to the paralimbic areas thatwere volumetrically reduced. Conclusion: Findings using our methods have implications for understandingbrain abnormalities in schizophrenia and suggest the importance of the paralimbic areas and their connections with prefrontal brain regions.

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Documento generato il 26/01/20 alle ore 09:55:58