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Titolo:
Evidence for a novel set of small heat-shock proteins that associates withthe mitochondria of murine PC12 cells and protects NADH : ubiquinone oxidoreductase from heat and oxidative stress
Autore:
Downs, CA; Jones, LR; Heckathorn, SA;
Indirizzi:
Univ Charleston, Dept Biol, Charleston, SC 29424 USA Univ Charleston Charleston SC USA 29424 pt Biol, Charleston, SC 29424 USA Univ Charleston, Dept Phys, Charleston, SC 29424 USA Univ Charleston Charleston SC USA 29424 pt Phys, Charleston, SC 29424 USA
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 2, volume: 365, anno: 1999,
pagine: 344 - 350
SICI:
0003-9861(19990515)365:2<344:EFANSO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; ALPHA-B-CRYSTALLIN; NEUROSPORA-CRASSA; GENE; THERMOTOLERANCE; DEHYDROGENASE; EXPRESSION; NEURODEGENERATION; PHOSPHORYLATION; ANTHRACYCLINES;
Keywords:
small heat-shock protein; mitochondria; heat stress; oxidative stress; oxidative phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Downs, CA Univ Charleston, Dept Biol, 58 Coming St, Charleston, SC 29424 USA Univ Charleston 58 Coming St Charleston SC USA 29424 C 29424 USA
Citazione:
C.A. Downs et al., "Evidence for a novel set of small heat-shock proteins that associates withthe mitochondria of murine PC12 cells and protects NADH : ubiquinone oxidoreductase from heat and oxidative stress", ARCH BIOCH, 365(2), 1999, pp. 344-350

Abstract

Several previously unreported small heat-shock proteins (sHsps) were detected in mitochondria from heat-stressed rat PC12 cells, but not in unstressed controls. Functional inactivation of the mitochondrial sHsps with murine Hsp25 antibody indicated that these sHsps protect NADH:ubiquinone oxidoreductase and NADH dehydrogenase activity (i.e., complex I) in submitochondrialvesicles during heat and oxidative stress. These results (i) confirm the existence of multiple sHsps in mammals and indicate that several of these sHsps associate with the mitochondria, (ii) indicate a conserved function between plant and mammalian mitochondrial sHsps in protecting electron transport during stress,and (iii) suggest that these sHsps may play an important role in diseases whose etiology is based upon oxidative damage of complex I. (C) 1999 Academic Press.

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Documento generato il 25/01/20 alle ore 15:58:54