Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bioaccumulation of trimethoprim, sulfamethoxazole and N-acetyl-sulfamethoxazole in Artemia nauplii and residual kinetics in seabass larvae after repeated oral dosing of medicated nauplii
Autore:
Touraki, M; Niopas, I; Kastritsis, C;
Indirizzi:
Aristotleabniv Thessaloniki, Fac Sci, Sch Biol, Dept Genet Dev & Mol Biol,L Aristotle Univ Thessaloniki Thessaloniki Greece 54006 t Dev & Mol Biol,L AristotlePharmacol,saloniki, Fac Hlth Sci, Sch Pharm, Dept Pharmacognosy &Aristotle Univ Thessaloniki Thessaloniki Greece 54006 pt Pharmacognosy &
Titolo Testata:
AQUACULTURE
fascicolo: 1-2, volume: 175, anno: 1999,
pagine: 15 - 30
SICI:
0044-8486(19990430)175:1-2<15:BOTSAN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMON SALMO-SALAR; INFECTIOUS-DISEASES; LIVE-FOOD; FISH; BIOENCAPSULATION; DELIVERY; EFFICACY; SULFADIMETHOXINE; TISSUE; ACID;
Keywords:
sulfamethoxazole; trimethoprin; N-acetyl sulfamethoxazole; Artemia nauplii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kastritsis, C Aristotleabniv Thessaloniki, Fac Sci, Sch Biol, Dept Genet Dev & Mol Biol,L Aristotle Univ Thessaloniki Thessaloniki Greece 54006 ol,L
Citazione:
M. Touraki et al., "Bioaccumulation of trimethoprim, sulfamethoxazole and N-acetyl-sulfamethoxazole in Artemia nauplii and residual kinetics in seabass larvae after repeated oral dosing of medicated nauplii", AQUACULTURE, 175(1-2), 1999, pp. 15-30

Abstract

The pharmacokinetics of trimethoprim (TMP), sulfamethoxazole (SMX) and itsmetabolite N-acetyl-sulfamethoxazole (N-acetyl-SMX), were studied in Artemia nauplii as a function of the duration and temperature of their storage, following their enrichment with the therapeutics using the bioencapsulationtechnique. A marked decrease in the therapeutic content of the nauplii wasobserved upon storage at 18 degrees C and 25 degrees C and it was concluded that medicated nauplii should either be administered fresh to fish larvaeor after storage for 8 h at 5 degrees C, at the most. Under the latter conditions, satisfactory levels of TMP and SMX were achieved, high survival rates and dry weight contents of the nauplii were preserved and minimal leakage of the therapeutics to the environment was secured. Treatment of seabasslarvae with one, three, six or ten doses of medicated Artemia nauplii, showed that maximum levels of the therapeutics are achieved in fish larvae when 10 doses are used. Following the treatment scheme of oral administration of 10 doses of medicated Artemia nauplii to fish larvae, the residual kinetics of TMP, SMX and N-acetyl-sulfamethoxazole were studied in seabass larvae. TMP and SMX showed different kinetic characteristics. A steady state of SMX concentration is considered to be achieved in fish body tissue during the 5-day medication period. TMP, SMX as well as the metabolite N-acetyl-sulfamethoxazole, were detectable in small amounts in fish body tissue even 100 h-post treatment. These data suggest that oral medication of fish larvae through the use of Artemia nauplii as a carrier of therapeutics, appears tobe a quite promising approach to be used as an alternative method of treatment, which could minimize some of the problems arising from the methods currently in use. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:15:29