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Titolo:
Detection of p53 protein accumulation in sputum and lung adenocarcinoma associated with indoor exposure to unvented coal smoke in China
Autore:
Mumford, JL; Tian, DF; Younes, M; Hu, FD; Lan, Q; Ostrowski, ML; He, YZ; Feng, ZM;
Indirizzi:
US EPA, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711US EPA, Res Triangle Pk, NC 27711 USA Univ N Carolina, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NCUSA 27599 olina, Chapel Hill, NC 27599 USA Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pathol, Houston, TX 77030 USA Yunnan Prov First Peoples Hosp, Kunming, Peoples R China Yunnan Prov FirstPeoples Hosp Kunming Peoples R China Peoples R China Inst Environm Hlth & Engn, Beijing, Peoples R China Inst Environm Hlth & Engn Beijing Peoples R China jing, Peoples R China
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2A, volume: 19, anno: 1999,
pagine: 951 - 958
SICI:
0250-7005(199903/04)19:2A<951:DOPPAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; CLINICAL IMPLICATIONS; CANCER DETECTION; XUAN-WEI; EXPRESSION; MUTATIONS; LESIONS;
Keywords:
lng adenocarcinoma; sputum; p53 protein accumulation; coal combustion emissions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mumford, JL US EPA, MD 58C, Res Triangle Pk, NC 27711 USA US EPA MD 58C Res Triangle Pk NC USA 27711 le Pk, NC 27711 USA
Citazione:
J.L. Mumford et al., "Detection of p53 protein accumulation in sputum and lung adenocarcinoma associated with indoor exposure to unvented coal smoke in China", ANTICANC R, 19(2A), 1999, pp. 951-958

Abstract

Lung cancer in Xuan Wei (XW), China has been linked to exposure to unvented coal smoke and adenocarcinoma, especially bronchioloalveolar carcinoma, is most common, p53 mutations occur commonly in lung cancers and usually generate detectable levels of p53 protein accumulation. Sputum is noninvasive to collect and ideal for screening p53 abnormalities, p53 protein accumulation was detected by immunohistochemistry in lung tumors and sputa from XW lung cancer patients to determine (1) the role of p53 in lung pathogenesis, and (2) feasibility of detecting p53 protein accumulation in sputum. p53 protein accumulation was detected in 73% (22/30) of lung adenocarcinomas fromXW females exposed to coal emissions and significantly higher than the control cases (33%, p<0.05). In sputum, we detected p53 overexpression in tumor cells in 54% (13/24) of XW cases and also in dysplastic cells (50% or 4/8). These findings suggest that p53 abnormalities is important in XW lung cancer etiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 14:46:33