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Titolo:
Functional imaging and detection of local recurrence in soft tissue sarcomas by positron emission tomography
Autore:
Schwarzbach, M; Willeke, F; Dimitrakopoulou-Strauss, A; Strauss, LG; Zhang, YM; Mechtersheimer, G; Hinz, U; Lehnert, T; Herfarth, C;
Indirizzi:
Univ Heidelberg, Dept Surg, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Div Surg Oncol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg Germany D-69120 lberg, Germany Univ Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 2B, volume: 19, anno: 1999,
pagine: 1343 - 1349
SICI:
0250-7005(199903/04)19:2B<1343:FIADOL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-AMINOISOBUTYRIC ACID; COMPUTED-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; MUSCULOSKELETAL TUMORS; LIMB PERFUSION; FDG-PET; TRANSPORT;
Keywords:
soft tissue sarcoma; positron emission tomography; fluorodeoxyglucose; aminoisobutyric acid; oxygen-labeled water;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzbach, M Univnyeidelberg, Dept Surg, Neuenheimer Feld 110, D-69120 Heidelberg, Germa Univ Heidelberg Neuenheimer Feld 110 Heidelberg Germany D-69120
Citazione:
M. Schwarzbach et al., "Functional imaging and detection of local recurrence in soft tissue sarcomas by positron emission tomography", ANTICANC R, 19(2B), 1999, pp. 1343-1349

Abstract

Background: Besides anatomically-based radiodiagnostics, functional imaging may be used for characterizing soft tissue sarcomas (STS). This study evaluates positron emission tomography (PET) with three different radiotracers(fluorine-18 deoxyglucose [FDG], carbon-11 aminoisobutyric acid [AIB] and oxygen-15-labeled water [O15-water]) for imaging STS and the detection of local recurrence. Patients and Methods: 21 patients presented with 9 primarySTS, 5 recurrent STS and 10 lesions suspicious for local recurrence (radiological tomography). Standardized uptake values (SW) were calculated in tumor and normal tissues (muscle/blood vessels). Surgery with pathological examination or follow-lip data were referred to as control criteria. Results: All tracers accumulated in STS with no difference between primary and locally recurrent tumors. The uptake in STS was increased compared to muscle (FDG, P < 0.0001; AIB, P = 0.0039; O15-water, P = 0.002) and to blood vessels for FDG (P < 0.0001) as well as AIB (P = 0.0038). Of 10 patients with suspected recurrence, 6 presented neither PET criteria for recurrence nor local failure in the specimens ol during follow-up, while 4 cases with positive PET scans were ultimately diagnosed with local failure. Conclusion: Besides FDG, AIB and O15-water were shown to accumulate in primary and recurrent STS of different histologic type. A precise differentiation from normal muscle was found for all tracers. FDG and AIB differentiated viable tumor from blood vessels. PET using FDG, AIB and O15-water is suitable for functional imaging of STS and the detection of sarcoma recurrence.

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Documento generato il 28/09/20 alle ore 14:09:21